• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

DEK 高表达预示胃腺癌预后不良。

High expression of DEK predicts poor prognosis of gastric adenocarcinoma.

机构信息

Department of Pathology, Yanbian University Medical College, No, 977, Gongyuan-Rd, Yanji 133002, China.

出版信息

Diagn Pathol. 2014 Mar 20;9:67. doi: 10.1186/1746-1596-9-67.

DOI:10.1186/1746-1596-9-67
PMID:24650035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3994479/
Abstract

BACKGROUND

DEK, as an oncoprotein, plays an important role in cancer development and progression. This study aimed to investigate the clinicopathological significance of DEK overexpression in patients with gastric cancer.

MATERIALS AND METHODS

The expression of DEK protein was evaluated by immunohistochemical (IHC) staining of 172 gastric cancer samples with complete clinicopathological features, and the correlation between DEK expression and clinicopathological features was examined. Survival rates were also calculated using the Kaplan-Meier method in gastric cancer patients with complete survival data.

RESULTS

DEK protein showed a strictly nuclear staining pattern in gastric cancers with IHC and immunofluorescence. The strongly positive rate of DEK protein was 60.5% (104/172) in gastric cancers, which was significantly higher than that in either gastric dysplasia (19.4%, 7/36) or adjacent normal mucosa (0%, 0/27). DEK expression in gastric cancer correlated to tumor size, differentiation, clinical stage, disease-free survival, and overall survival rates. Further analysis showed that patients with early-stage gastric cancer and high DEK expression had shorter disease-free survival and overall survival duration than those with low DEK expression.

CONCLUSION

High level of DEK protein expression predicts the poor prognosis of patients with gastric cancer. DEK expression might be potentially used as an independent effective biomarker for prognostic evaluation of gastric cancers.

VIRTUAL SLIDES

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5050145571193097.

摘要

背景

DEK 作为一种癌蛋白，在癌症的发生和发展中起着重要作用。本研究旨在探讨 DEK 过表达在胃癌患者中的临床病理意义。

材料与方法

采用免疫组化（IHC）染色法检测 172 例具有完整临床病理特征的胃癌样本中 DEK 蛋白的表达情况，并分析 DEK 表达与临床病理特征的相关性。对具有完整生存数据的胃癌患者，采用 Kaplan-Meier 法计算生存率。

结果

DEK 蛋白在胃癌中的 IHC 和免疫荧光染色呈严格的核染色模式。胃癌中 DEK 蛋白强阳性率为 60.5%（104/172），明显高于胃黏膜异型增生（19.4%，7/36）和癌旁正常黏膜（0%，0/27）。DEK 表达与肿瘤大小、分化程度、临床分期、无病生存率和总生存率有关。进一步分析显示，早期胃癌和高 DEK 表达的患者无病生存率和总生存率均短于低 DEK 表达的患者。

结论

DEK 蛋白高水平表达预示着胃癌患者预后不良。DEK 表达可能作为预测胃癌患者预后的一个独立有效标志物。

虚拟幻灯片

本文的虚拟幻灯片可以在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/5050145571193097.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/70332c0837ce/1746-1596-9-67-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/80b4d3dab446/1746-1596-9-67-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/f4adb3705078/1746-1596-9-67-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/dfb741bf90a3/1746-1596-9-67-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/70332c0837ce/1746-1596-9-67-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/80b4d3dab446/1746-1596-9-67-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/f4adb3705078/1746-1596-9-67-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/dfb741bf90a3/1746-1596-9-67-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b440/3994479/70332c0837ce/1746-1596-9-67-4.jpg

相似文献

1
High expression of DEK predicts poor prognosis of gastric adenocarcinoma.DEK 高表达预示胃腺癌预后不良。
Diagn Pathol. 2014 Mar 20;9:67. doi: 10.1186/1746-1596-9-67.
2
DEK over expression as an independent biomarker for poor prognosis in colorectal cancer.DEK 过表达作为结直肠癌不良预后的独立生物标志物。
BMC Cancer. 2013 Jul 31;13:366. doi: 10.1186/1471-2407-13-366.
3
High expression of oncoprotein DEK predicts poor prognosis of small cell lung cancer.癌蛋白DEK的高表达预示小细胞肺癌预后不良。
Int J Clin Exp Pathol. 2014 Jul 15;7(8):5016-23. eCollection 2014.
4
Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma.Ezrin 过表达预示着胃腺癌预后不良。
Diagn Pathol. 2012 Oct 5;7:135. doi: 10.1186/1746-1596-7-135.
5
Prognostic impact of TAZ and β-catenin expression in adenocarcinoma of the esophagogastric junction.胃食管结合部腺癌中 TAZ 和 β-连环蛋白表达的预后影响。
Diagn Pathol. 2014 Jul 16;9:125. doi: 10.1186/1746-1596-9-125.
6
DEK Is a Potential Biomarker Associated with Malignant Phenotype in Gastric Cancer Tissues and Plasma.DEK 是胃癌组织和血浆中与恶性表型相关的潜在生物标志物。
Int J Mol Sci. 2019 Nov 13;20(22):5689. doi: 10.3390/ijms20225689.
7
DEK protein overexpression predicts poor prognosis in pancreatic ductal adenocarcinoma.DEK蛋白过表达预示胰腺导管腺癌预后不良。
Oncol Rep. 2017 Feb;37(2):857-864. doi: 10.3892/or.2016.5302. Epub 2016 Dec 8.
8
Nuclear overexpression of the overexpressed in lung cancer 1 predicts worse prognosis in gastric adenocarcinoma.肺癌中过表达的1在细胞核中过表达预示胃腺癌预后更差。
Oncotarget. 2017 Feb 7;8(6):9442-9450. doi: 10.18632/oncotarget.14217.
9
Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma.DEK过表达对非小细胞肺癌预后评估的意义
Oncol Rep. 2016 Jan;35(1):155-62. doi: 10.3892/or.2015.4365. Epub 2015 Oct 30.
10
Decreased expression of SEMA3A is associated with poor prognosis in gastric carcinoma.SEMA3A表达降低与胃癌预后不良相关。
Int J Clin Exp Pathol. 2014 Jul 15;7(8):4782-94. eCollection 2014.

引用本文的文献

1
DEK facilitates bortezomib resistance of multiple myeloma by modulating ferroptosis.DEK通过调节铁死亡促进多发性骨髓瘤对硼替佐米的耐药性。
Clin Exp Med. 2025 Jul 17;25(1):252. doi: 10.1007/s10238-025-01673-4.
2
Proto-oncogene DEK binds to pre-mRNAs and regulates the alternative splicing of Hippo signaling genes in HeLa cells.原癌基因DEK与前体mRNA结合并调节HeLa细胞中Hippo信号基因的可变剪接。
Mol Genet Genomics. 2025 Mar 13;300(1):31. doi: 10.1007/s00438-025-02226-w.
3
The effects of compound probiotics on production performance, rumen fermentation and microbiota of sheep.

本文引用的文献

1
The association between chemosensitivity and Pgp, GST-π and Topo II expression in gastric cancer.胃癌中化疗敏感性与 Pgp、GST-π 和 Topo II 表达的关系。
Diagn Pathol. 2013 Dec 10;8:198. doi: 10.1186/1746-1596-8-198.
2
The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues. Claudin-10、-14、-17 和 E-钙黏蛋白在相邻非肿瘤组织和胃癌组织中的表达模式存在明显差异。
Diagn Pathol. 2013 Dec 10;8:205. doi: 10.1186/1746-1596-8-205.
3
Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.
复合益生菌对绵羊生产性能、瘤胃发酵及微生物群的影响
Front Vet Sci. 2024 Oct 31;11:1440432. doi: 10.3389/fvets.2024.1440432. eCollection 2024.
4
Super-resolution microscopy reveals the nanoscale cluster architecture of the DEK protein cancer biomarker.超分辨率显微镜揭示了DEK蛋白癌症生物标志物的纳米级簇结构。
iScience. 2023 Oct 19;26(11):108277. doi: 10.1016/j.isci.2023.108277. eCollection 2023 Nov 17.
5
Novel molecular mechanisms in Alzheimer's disease: The potential role of DEK in disease pathogenesis.阿尔茨海默病中的新型分子机制：DEK在疾病发病机制中的潜在作用。
Front Aging Neurosci. 2022 Oct 6;14:1018180. doi: 10.3389/fnagi.2022.1018180. eCollection 2022.
6
Long Non-Coding LEF1-AS1 Sponge miR-5100 Regulates Apoptosis and Autophagy in Gastric Cancer Cells via the miR-5100/DEK/AMPK-mTOR Axis.长链非编码 LEF1-AS1 通过 miR-5100/DEK/AMPK-mTOR 轴调控胃癌细胞凋亡和自噬。
Int J Mol Sci. 2022 Apr 26;23(9):4787. doi: 10.3390/ijms23094787.
7
DEK modulates both expression and alternative splicing of cancer‑related genes.DEK 调节与癌症相关基因的表达和选择性剪接。
Oncol Rep. 2022 Jun;47(6). doi: 10.3892/or.2022.8322. Epub 2022 Apr 27.
8
Exosomal DEK removes chemoradiotherapy resistance by triggering quiescence exit of breast cancer stem cells.外泌体 DEK 通过触发乳腺癌干细胞静止期退出而消除化学放疗抵抗。
Oncogene. 2022 Apr;41(18):2624-2637. doi: 10.1038/s41388-022-02278-x. Epub 2022 Mar 29.
9
Gigantol inhibits cell proliferation and induces apoptosis by regulating DEK in non-small cell lung cancer.吉非替尼通过调节非小细胞肺癌中的DEK来抑制细胞增殖并诱导细胞凋亡。
Exp Ther Med. 2021 Nov;22(5):1317. doi: 10.3892/etm.2021.10752. Epub 2021 Sep 17.
10
Sevoflurane Limits Glioma Progression by Regulating Cell Proliferation, Apoptosis, Migration, and Invasion via miR-218-5p/DEK/β-Catenin Axis in Glioma.七氟醚通过miR-218-5p/DEK/β-连环蛋白轴调控胶质瘤细胞的增殖、凋亡、迁移和侵袭来限制胶质瘤进展。
Cancer Manag Res. 2021 Feb 26;13:2057-2069. doi: 10.2147/CMAR.S265356. eCollection 2021.
黄芪皂苷影响胃癌 BGC-823 细胞的增殖、侵袭和凋亡。
Diagn Pathol. 2013 Oct 24;8:179. doi: 10.1186/1746-1596-8-179.
4
Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR.DEK-NUP214融合蛋白的强制表达通过mTOR的上调促进增殖。
BMC Cancer. 2013 Sep 27;13:440. doi: 10.1186/1471-2407-13-440.
5
DEK over expression as an independent biomarker for poor prognosis in colorectal cancer.DEK 过表达作为结直肠癌不良预后的独立生物标志物。
BMC Cancer. 2013 Jul 31;13:366. doi: 10.1186/1471-2407-13-366.
6
DEK depletion negatively regulates Rho/ROCK/MLC pathway in non-small cell lung cancer.DEK 缺失负调控非小细胞肺癌中的 Rho/ROCK/MLC 通路。
J Histochem Cytochem. 2013 Jul;61(7):510-21. doi: 10.1369/0022155413488120. Epub 2013 Apr 9.
7
Ezrin overexpression predicts the poor prognosis of gastric adenocarcinoma.Ezrin 过表达预示着胃腺癌预后不良。
Diagn Pathol. 2012 Oct 5;7:135. doi: 10.1186/1746-1596-7-135.
8
Exocrine and endocrine modulation in common gastric carcinoma.常见胃癌的外分泌和内分泌调节。
Am J Clin Pathol. 2012 May;137(5):712-21. doi: 10.1309/AJCPM13KVNCZQBUV.
9
DEK overexpression is correlated with the clinical features of breast cancer.DEK 过表达与乳腺癌的临床特征相关。
Pathol Int. 2012 Mar;62(3):176-81. doi: 10.1111/j.1440-1827.2011.02775.x. Epub 2012 Jan 13.
10
[WHO Classification of digestive tumors: the fourth edition].[世界卫生组织消化系统肿瘤分类：第四版]
Ann Pathol. 2011 Nov;31(5 Suppl):S27-31. doi: 10.1016/j.annpat.2011.08.001. Epub 2011 Sep 3.