Department of Psychiatry, University of California San Francisco, San Francisco, California, USA.
The Neurology Center of Southern California, Carlsbad, California, USA.
Alzheimers Dement. 2020 Oct;16(10):1384-1392. doi: 10.1002/alz.12134. Epub 2020 Jul 12.
We created a summary score for multiple sensory (multisensory) impairment and evaluated its association with dementia.
We studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were assessed in regression models adjusting for demographics and health conditions.
Dementia risk was 2.05 times higher (95% confidence interval [CI] 1.50-2.81) comparing "poor" to "good" multisensory score tertiles and 1.45 times higher comparing the "middle" to "good" tertiles (95% CI 1.09-1.91). Each point worse in the multisensory function score was associated with faster rates of cognitive decline (P < .05).
Worsening multisensory function, even at mild levels, was associated with accelerated cognitive aging.
我们创建了一个多感官（多感官）障碍综合评分，并评估其与痴呆的相关性。
我们研究了 1794 名年龄在 70 至 79 岁、入组时无痴呆的成年人，并在健康、衰老和身体成分研究中进行了长达 10 年的随访。多感官功能评分（0 至 12 分）基于客观测量的视力、听力、嗅觉和触觉的样本四分位数总和。使用回归模型调整人口统计学和健康状况后，评估了该评分与新发痴呆和认知能力下降（通过两项认知测试测量）的相关性。
与“良好”到“差”多感官评分三分位相比，“差”与“良好”三分位相比，痴呆风险高 2.05 倍（95%置信区间 [CI] 1.50-2.81），与“中”与“良好”三分位相比，痴呆风险高 1.45 倍（95%CI 1.09-1.91）。多感官功能评分每降低 1 分，认知衰退速度就会加快（P<.05）。
即使是轻度的多感官功能恶化也与认知衰老加速有关。
