Lad Meher, Taylor John-Paul, Griffiths Tim D
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.
Heliyon. 2024 May 3;10(9):e30423. doi: 10.1016/j.heliyon.2024.e30423. eCollection 2024 May 15.
Hearing loss is a risk-factor for dementia but the reasons for this are unclear. Subjective hearing loss is related to increased future dementia risk, however, this metric has not been previously examined with cognitive, neuroimaging and biochemical measures that are relevant to Alzheimer's disease. We assessed Cognitively Normal and Mild Cognitively Impaired participants from the Alzheimer's Disease Neuroimaging Initiative with subjective hearing loss to examine if they had faster decline in episodic memory scores, hippocampal volume and greater pTau positivity. The likelihood of a dementia diagnosis in hearing impaired participants over a 5-year period was also assessed. There were no statistically significant differences between the hearing subgroups over a 5-year period nor were there in conversions to a dementia diagnosis. Objective hearing loss metrics may provide a more reliable link between hearing loss and dementia risk.
听力损失是痴呆症的一个风险因素，但其原因尚不清楚。主观听力损失与未来患痴呆症的风险增加有关，然而，此前尚未通过与阿尔茨海默病相关的认知、神经影像学和生化指标对这一指标进行研究。我们对来自阿尔茨海默病神经影像学计划的认知正常和轻度认知障碍参与者进行主观听力损失评估，以检查他们的情景记忆分数、海马体积下降是否更快以及pTau阳性是否更高。还评估了听力受损参与者在5年内被诊断为痴呆症的可能性。在5年期间，听力亚组之间在统计学上没有显著差异，在转为痴呆症诊断方面也没有差异。客观听力损失指标可能在听力损失和痴呆症风险之间提供更可靠的联系。
