Parks R W, Loewenstein D A, Dodrill K L, Barker W W, Yoshii F, Chang J Y, Emran A, Apicella A, Sheramata W A, Duara R
Department of Radiology, Mount Sinai Medical Center, Miami Beach, FL 33140.
J Clin Exp Neuropsychol. 1988 Oct;10(5):565-75. doi: 10.1080/01688638808402795.
Sixteen normal volunteers were studied with [F-18] fluorodeoxyglucose and positron emission tomography scans during behavioral activation with a verbal fluency test, and 35 age-matched controls were studied with resting-state scans. There was an overall increase of the cerebral glucose metabolic rate of 23.3% during verbal fluency activation, compared to the resting state, with the greatest activation in bilateral temporal and frontal lobes. A negative correlation between test performance scores and indices of metabolism was found in frontal, temporal, and parietal regions. Damage to the left frontal lobe maximally affects scores on verbal fluency tests, but performing the test activates a network of regions, of which the left frontal lobe is only one. Proficient performance in verbal fluency seems to require less metabolic activation than poor performance, perhaps because of the efficiency of cognitive strategies employed.
16名正常志愿者在进行语言流畅性测试的行为激活过程中接受了[F-18]氟脱氧葡萄糖和正电子发射断层扫描，35名年龄匹配的对照者接受了静息状态扫描。与静息状态相比，语言流畅性激活期间大脑葡萄糖代谢率总体增加了23.3%，双侧颞叶和额叶激活最为明显。在额叶、颞叶和顶叶区域发现测试表现得分与代谢指标之间呈负相关。左侧额叶损伤对语言流畅性测试得分影响最大，但进行测试会激活一个区域网络，其中左侧额叶只是其中之一。语言流畅性方面的熟练表现似乎比表现不佳需要更少的代谢激活，这可能是由于所采用认知策略的效率。
