Duara R, Gross-Glenn K, Barker W W, Chang J Y, Apicella A, Loewenstein D, Boothe T
J Cereb Blood Flow Metab. 1987 Jun;7(3):266-71. doi: 10.1038/jcbfm.1987.62.
Variability in cerebral glucose metabolism was examined between and within subjects when paired studies were performed in the resting state or in a behaviorally activated state. Both normal and demented subjects were studied twice each, from 1 to 6 weeks apart, under near-identical conditions, using positron emission tomography (PET) and [18F]fluorodeoxyglucose. Resting state studies were repeated in nine normal and four demented subjects. A picture-viewing test, used for activation during PET, was used repeatedly in seven normal and five demented subjects. Within-subject variability, as assessed by the percent difference in metabolic rates in paired studies, was reduced by 60-70% for activation state compared to resting state studies in normals. It is concluded that PET studies of brain metabolism, which are designed to study the active brain, should indeed be performed in functionally activated states, as in addition to demonstrating metabolism during a defined functional state, activation studies show reduced variability of cerebral metabolic measures.
当在静息状态或行为激活状态下进行配对研究时，对受试者之间和受试者内部的脑葡萄糖代谢变异性进行了检查。正常受试者和痴呆受试者均接受两次研究，每次研究间隔1至6周，在近乎相同的条件下，使用正电子发射断层扫描（PET）和[18F]氟脱氧葡萄糖。对9名正常受试者和4名痴呆受试者重复进行静息状态研究。在7名正常受试者和5名痴呆受试者中，反复使用用于PET激活的图片观看测试。与正常受试者静息状态研究相比，激活状态下配对研究中代谢率百分比差异评估的受试者内部变异性降低了60%-70%。得出的结论是，旨在研究活跃大脑的脑代谢PET研究确实应在功能激活状态下进行，因为除了在特定功能状态下证明代谢外，激活研究还显示脑代谢测量的变异性降低。
