18F-THK5351 PET 可识别急性创伤性脑损伤的病灶。

18F-THK5351 PET Can Identify Lesions of Acute Traumatic Brain Injury.

机构信息

From the Departments of Radiology.

Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan.

出版信息

Clin Nucl Med. 2020 Nov;45(11):e491-e492. doi: 10.1097/RLU.0000000000003165.

DOI:10.1097/RLU.0000000000003165

PMID:32657863

Abstract

A 67-year-old woman sustained a mild traumatic brain injury (TBI) in a traffic accident and had an initial Glasgow Coma Scale score of 13. She underwent F-THK5351 PET 18 days after TBI. Fused F-THK5351 PET/MRI showed that the location of F-THK5351 accumulations corresponded anatomically to intraparenchymal lesions of acute TBI on MRI. F-THK5351 reportedly binds to monoamine oxidase B highly expressed in astrocytes. Furthermore, TBI induces reactive astrogliosis or blood-brain barrier breakdown included in primary brain injury. Therefore, F-THK5351 uptake may represent primary brain injury in acute TBI lesions.

摘要

一位 67 岁女性在交通事故中遭受轻度创伤性脑损伤（TBI），初始格拉斯哥昏迷评分（GCS）为 13。她在 TBI 后 18 天行 F-THK5351 PET 检查。融合 F-THK5351 PET/MRI 显示 F-THK5351 聚集的位置与 MRI 上急性 TBI 的脑实质病变在解剖学上相对应。据报道，F-THK5351 与高度表达于星形胶质细胞的单胺氧化酶 B 结合。此外，TBI 诱导包括原发性脑损伤在内的反应性星形胶质增生或血脑屏障破坏。因此，F-THK5351 摄取可能代表急性 TBI 病变中的原发性脑损伤。