18F-THK5351 PET 可识别多发性硬化斑块中的星形胶质细胞增生。
18F-THK5351 PET Can Identify Astrogliosis in Multiple Sclerosis Plaques.
机构信息
Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
From the Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology.
出版信息
Clin Nucl Med. 2020 Feb;45(2):e98-e100. doi: 10.1097/RLU.0000000000002751.
A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 accumulations corresponded anatomically to MS plaques identified by MRI. Because F-THK5351 binds to monoamine oxidase B highly expressed in astrocytes, F-THK5351 accumulates in lesions undergoing astrogliosis. Hence, elevated uptake of F-THK5351 in the present case can represent ongoing astrogliosis in inactive MS lesions (plaques).
一位 26 岁患有复发缓解型多发性硬化症（MS）的女性在缓解期接受了 F-THK5351 PET 检查。PET 成像显示，大脑中散布着 F-THK5351 摄取增加的小区域，并且 F-THK5351 聚集的焦点在解剖学上与 MRI 确定的 MS 斑块相对应。因为 F-THK5351 与高度表达于星形胶质细胞的单胺氧化酶 B 结合，所以 F-THK5351 在经历星形胶质细胞增生的病变中积聚。因此，在本病例中 F-THK5351 的摄取增加可以代表静止 MS 病变（斑块）中的持续星形胶质细胞增生。
Zotero 插件