Department of Neurology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
From the Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology.
Clin Nucl Med. 2020 Feb;45(2):e98-e100. doi: 10.1097/RLU.0000000000002751.
A 26-year-old woman with relapsing-remitting multiple sclerosis (MS) underwent F-THK5351 PET during a remission period. PET imaging showed that small regions with elevated uptake of F-THK5351 were scattered in the brain and that the foci of F-THK5351 accumulations corresponded anatomically to MS plaques identified by MRI. Because F-THK5351 binds to monoamine oxidase B highly expressed in astrocytes, F-THK5351 accumulates in lesions undergoing astrogliosis. Hence, elevated uptake of F-THK5351 in the present case can represent ongoing astrogliosis in inactive MS lesions (plaques).
一位 26 岁患有复发缓解型多发性硬化症（MS）的女性在缓解期接受了 F-THK5351 PET 检查。PET 成像显示，大脑中散布着 F-THK5351 摄取增加的小区域，并且 F-THK5351 聚集的焦点在解剖学上与 MRI 确定的 MS 斑块相对应。因为 F-THK5351 与高度表达于星形胶质细胞的单胺氧化酶 B 结合，所以 F-THK5351 在经历星形胶质细胞增生的病变中积聚。因此，在本病例中 F-THK5351 的摄取增加可以代表静止 MS 病变（斑块）中的持续星形胶质细胞增生。
