18F-THK5351 PET 对识别脑梗死所致锥体束华勒氏变性的潜在应用。
Potential Use of 18F-THK5351 PET to Identify Wallerian Degeneration of the Pyramidal Tract Caused by Cerebral Infarction.
机构信息
From the *Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology; and †Department of Nuclear Medicine, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.
出版信息
Clin Nucl Med. 2017 Dec;42(12):e523-e524. doi: 10.1097/RLU.0000000000001868.
A 41-year-old man underwent F-THK5351 PET 2 years after a right middle cerebral artery infarction. F-THK5351 PET imaging revealed intense radioligand uptake along the ipsilateral pyramidal tract from the corona radiata to the medulla; intense uptake changed from the right side to the left side with descending axial sections at the level of the pyramidal decussation. F-THK5351 reportedly binds to monoamine oxidase B, which is highly expressed in astrocytes, suggesting that F-THK5351 concentrates in the lesion where gliosis occurs. Hence, in this case, F-THK5351 uptake may represent Wallerian degeneration accompanied with gliosis in the ipsilateral pyramidal tract.
一位 41 岁男性在右侧大脑中动脉梗死 2 年后接受了 F-THK5351 PET 检查。F-THK5351 PET 成像显示，从放射冠到延髓，同侧的锥体束有强烈的放射性配体摄取；随着在锥体交叉水平的降轴位切片，摄取从右侧变为左侧。据报道，F-THK5351 与单胺氧化酶 B 结合，后者在星形胶质细胞中高度表达，提示 F-THK5351 在发生神经胶质增生的病变部位聚集。因此，在本例中，F-THK5351 的摄取可能代表了伴有同侧锥体束神经胶质增生的沃勒氏变性。
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