Department of Biobehavioral Health, The Pennsylvania State University.
Exp Clin Psychopharmacol. 2021 Feb;29(1):116-135. doi: 10.1037/pha0000382. Epub 2020 Jul 13.
Worldwide, smoking remains a threat to public health, causing preventable diseases and premature mortality. Cigarette smoke is a powerful inducer of DNA methylation and gene expression alterations, which have been associated with negative health consequences. Here, we review the current knowledge on smoking-related changes in DNA methylation and gene expression in human blood samples. We identified 30 studies focused on the association between active smoking, DNA methylation modifications, and gene expression alterations. Overall, we identified 1,758 genes with differentially methylated sites (DMS) and differentially expressed genes (DEG) between smokers and nonsmokers, of which 261 were detected in multiple studies (≥4). The most frequently (≥10 studies) reported genes were , , , and . Functional enrichment analysis of the 261 genes identified the aryl hydrocarbon receptor repressor and T cell pathways (T helpers 1 and 2) as influenced by smoking status. These results highlight specific genes for future mechanistic and translational research that may be associated with cigarette smoke exposure and smoking-related diseases. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
在全球范围内，吸烟仍然是对公众健康的威胁，导致可预防的疾病和过早死亡。香烟烟雾是 DNA 甲基化和基因表达改变的强大诱导剂，这些改变与负面健康后果有关。在这里，我们回顾了关于人类血液样本中与吸烟相关的 DNA 甲基化和基因表达改变的现有知识。我们确定了 30 项专注于主动吸烟、DNA 甲基化修饰和基因表达改变之间关联的研究。总的来说，我们在吸烟者和不吸烟者之间发现了 1758 个具有差异甲基化位点（DMS）和差异表达基因（DEG）的基因，其中 261 个在多个研究中被检测到（≥4）。报告频率最高的基因（≥10 项研究）为 、 、 、 。对 261 个基因的功能富集分析确定了芳烃受体抑制剂和 T 细胞途径（T 辅助 1 和 2）受吸烟状态的影响。这些结果突出了特定的基因，用于未来的机制和转化研究，这些研究可能与香烟烟雾暴露和与吸烟相关的疾病有关。（PsycInfo 数据库记录（c）2021 APA，保留所有权利）。
