Childs C, Little R A
Regional Paediatric Burns Unit, Booth Hall Children's Hospital, Manchester, UK.
Burns Incl Therm Inj. 1988 Oct;14(5):343-8. doi: 10.1016/0305-4179(88)90001-0.
Acetaminophen (paracetamol 12 mg/kg p.o.) was administered on a total of 33 occasions to 12 children (13-36 months of age) during the first 60 h after burn injury covering 10-44 per cent of the body surface area (BSA). The drug was effective in lowering rectal temperature on most (80 per cent) occasions; failure to elicit a response was not restricted to particular patients or patterns of injury. There was no evidence of tachyphylaxis to the antipyretic effects of acetaminophen. The pattern of change in the rectal and toe temperature after acetaminophen suggested that it may be acting by either increasing heat loss or by lowering heat production, both of which are consistent with a reduction in thermoregulatory setpoint mediated by inhibition of prostaglandin synthetase.
在烧伤后最初60小时内，对12名年龄在13至36个月、烧伤面积占体表面积（BSA）10%至44%的儿童，总共33次口服对乙酰氨基酚（扑热息痛，12毫克/千克）。在大多数（80%）情况下，该药能有效降低直肠温度；未能引起反应的情况并不局限于特定患者或损伤模式。没有证据表明对乙酰氨基酚的解热作用会产生快速耐受性。对乙酰氨基酚给药后直肠和脚趾温度的变化模式表明，其作用机制可能是增加散热或降低产热，这两者都与抑制前列腺素合成酶介导的体温调节设定点降低相一致。
