Polidori G, Titti G, Pieragostini P, Comito A, Scaricabarozzi I
Istituto di Clinica Pediatrica, Università Cattolica del Sacro Cuore, Rome, Italy.
Drugs. 1993;46 Suppl 1:231-3. doi: 10.2165/00003495-199300461-00059.
The efficacy and tolerability of nimesulide were compared with those of paracetamol in a nonblind randomised study that recruited 110 children (64 males, 46 females; aged 3 to 6 years) with inflammation of the upper respiratory tract and fever. Nimesulide suspension (1.5 mg/kg 3 times daily) or paracetamol syrup (10 mg/kg 4 times daily) were administered orally until fever resolved. Body temperature was recorded and local pain and general discomfort assessed. Three patients treated with nimesulide and 6 patients treated with paracetamol withdrew from the study as a result of adverse events, and 1 paracetamol-treated patient discontinued because of a requirement for therapy with steroids. Nimesulide was as effective as paracetamol in reducing fever, local pain, and general discomfort. Nimesulide therefore appears to be at least as effective as paracetamol in terms of antipyretic and anti-inflammatory activity in children with inflammation of the upper respiratory tract and fever.
在一项非盲法随机研究中，将尼美舒利与对乙酰氨基酚的疗效和耐受性进行了比较。该研究招募了110名患有上呼吸道炎症和发热的儿童（64名男性，46名女性；年龄3至6岁）。口服给予尼美舒利混悬液（1.5毫克/千克，每日3次）或对乙酰氨基酚糖浆（10毫克/千克，每日4次），直至发热消退。记录体温，并评估局部疼痛和全身不适情况。3名接受尼美舒利治疗的患者和6名接受对乙酰氨基酚治疗的患者因不良事件退出研究，1名接受对乙酰氨基酚治疗的患者因需要使用类固醇治疗而停药。在降低发热、局部疼痛和全身不适方面，尼美舒利与对乙酰氨基酚效果相当。因此，在患有上呼吸道炎症和发热的儿童中，就解热和抗炎活性而言，尼美舒利似乎至少与对乙酰氨基酚一样有效。
