新冠病毒与痴呆负担的相关性：一项生态学研究和文献综述。
Correlations between COVID-19 and burden of dementia: An ecological study and review of literature.
机构信息
Stroke Prevention and Atherosclerosis Research Centre, Robarts Research Institute, Western University, London, Ontario, Canada; Department of Clinical Neurological Sciences, Western University, London, Ontario, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
J Neurol Sci. 2020 Sep 15;416:117013. doi: 10.1016/j.jns.2020.117013. Epub 2020 Jul 4.
INTRODUCTION
Current evidence on the association between COVID-19 and dementia is sparse. This study aims to investigate the associations between COVID-19 caseload and the burden of dementia.
METHODS
We gathered data regarding burden of dementia (disability-adjusted life years [DALYs] per 100,000), life expectancy, and healthy life expectancy (HALE) from the Global Burden of Disease (GBD) 2017 study. We obtained COVID-19 data from Our World in Data database. We analyzed the association of COVID-19 cases and deaths with the burden of dementia using Spearman's rank correlation coefficient.
RESULTS
Globally, we found significant positive (p < .001) correlations between life expectancy (r = 0.60), HALE (r = 0.58), and dementia DALYs (r = 0.46) with COVID-19 caseloads. Likewise, we found similar correlations between life expectancy (r = 0.60), HALE (r = 0.58) and dementia DALYs (r = 0.54) with COVID-19 mortality.
CONCLUSION
Health policymakers should clarify a targeted model of disease surveillance in order to reduce the dual burden of dementia and COVID-19.
简介
目前关于 COVID-19 与痴呆症之间关联的证据有限。本研究旨在探讨 COVID-19 病例数与痴呆症负担之间的关联。
方法
我们从 2017 年全球疾病负担研究中收集了关于痴呆症负担（每 10 万人残疾调整生命年 [DALYs]）、预期寿命和健康期望寿命（HALE）的数据。我们从 Our World in Data 数据库获得了 COVID-19 数据。我们使用 Spearman 等级相关系数分析了 COVID-19 病例和死亡与痴呆症负担之间的关联。
结果
在全球范围内，我们发现预期寿命（r = 0.60）、HALE（r = 0.58）和痴呆症 DALYs（r = 0.46）与 COVID-19 病例数之间存在显著正相关（p < 0.001）。同样，我们发现预期寿命（r = 0.60）、HALE（r = 0.58）与痴呆症 DALYs（r = 0.54）之间存在类似的相关性与 COVID-19 死亡率。
结论
卫生政策制定者应明确针对疾病监测的目标模型，以降低痴呆症和 COVID-19 的双重负担。
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