Department of Rheumatology, School of Medicine, Fırat University, Elazığ, TURKEY
Department of Biology, Faculty of Science, Fırat University, Elazığ, TURKEY
Turk J Med Sci. 2020 Dec 17;50(8):2040-2047. doi: 10.3906/sag-2004-105.
BACKGROUND/AIM: Mango ginger (MG: curcuma amada) has antioxidant and antiinflammatory activities. The aim was to evaluate the antiarthritic potential efficacy of MG on collagen-induced arthritis.
Twenty-one female Wistar-albino rats were divided into three groups. Arthritis was induced by intradermal injections of type II collagen and Freund’s adjuvant. MG extract was orally administered starting from the first collagen injection. TNF-α, IL-6, IL-17, obestatin, sclerostin, and DKK-1 serum levels were determined, and perisynovial inflammation and cartilage-bone destruction in the paws were histologically evaluated. Moreover, joint tissue TNF-α, IL-17, NF-κB, and COX-2 levels were analyzed.
TNF-α, IL-17, IL-6, and DKK-1 serum levels were increased, and obestatin and sclerostin serum levels were decreased in the arthritis group compared to the control group. However, MG supplements decreased TNF-α, IL-17, IL-6, and DKK-1 serum levels and increased obestatin and sclerostin serum levels. Similarly, while collagen injection increased tissue TNF-α, IL-17, NF-κB, and COX-2 levels, MG decreased TNF-α, IL-17, and NF-κB levels. Moreover, MG ameliorated perisynovial inflammation and cartilage-bone destruction in the paws.
MG ameliorates arthritis via actions on inflammatory ways and wingless (Wnt) signaling pathway. These results suggest that MG may have a considerable potential efficacy for the treatment of rheumatoid arthritis.
背景/目的：芒果姜（MG：curcuma amada）具有抗氧化和抗炎作用。本研究旨在评估 MG 对胶原诱导性关节炎的潜在抗关节炎疗效。
21 只雌性 Wistar 白化大鼠分为三组。关节炎通过皮内注射 II 型胶原和弗氏佐剂诱导。MG 提取物从第一次注射胶原开始口服给药。测定 TNF-α、IL-6、IL-17、obestatin、sclerostin 和 DKK-1 血清水平，并对爪子的滑膜炎症和软骨-骨破坏进行组织学评估。此外，还分析了关节组织 TNF-α、IL-17、NF-κB 和 COX-2 水平。
与对照组相比，关节炎组 TNF-α、IL-17、IL-6 和 DKK-1 血清水平升高，obestatin 和 sclerostin 血清水平降低。然而，MG 补充剂降低了 TNF-α、IL-17、IL-6 和 DKK-1 血清水平，增加了 obestatin 和 sclerostin 血清水平。同样，胶原注射增加了组织 TNF-α、IL-17、NF-κB 和 COX-2 水平，而 MG 降低了 TNF-α、IL-17 和 NF-κB 水平。此外，MG 改善了爪子的滑膜炎症和软骨-骨破坏。
MG 通过对炎症途径和 Wnt 信号通路的作用改善关节炎。这些结果表明，MG 可能具有治疗类风湿性关节炎的相当大的潜力。
