Hospital for Sick Children, Respiratory Medicine, University of Toronto. Toronto, Canada.
Department of Medicine, Pulmonary Sciences and Critical Care. University of Colorado. Denver, CO, United States.
Paediatr Respir Rev. 2021 Mar;37:18-21. doi: 10.1016/j.prrv.2020.05.004. Epub 2020 May 30.
Obesity is an asthma comorbidity associated with poor control, increased exacerbation risk and reduced response to inhaled and systemic corticosteroids. It affects children and adults differentially. In those with early onset asthma, it associated with increased eosinophilic inflammation, whereas in late onset, it correlates with lower nitric oxide (NO) and predominantly non-T2 inflammation. There are probably multiple pathways by which obesity impacts asthma; airway and systemic oxidative stress has been proposed as a mechanism that could potentially explain the obesity mediated increased comorbidity and poor response to treatment. More likely than not, oxidative stress is an epiphenomenon of a very diverse set of processes driven by complex changes in airway and systemic metabolism. This article provides a comprehensive overview of the clinical, metabolic, pathophysiological and therapeutic aspects of oxidative stress in patients with obesity and asthma.
肥胖是哮喘的一种合并症，与控制不佳、加重风险增加以及对吸入和全身皮质类固醇的反应降低有关。它对儿童和成人的影响不同。在那些早期发病的哮喘患者中，它与嗜酸性粒细胞炎症增加有关，而在晚期发病的哮喘患者中，它与较低的一氧化氮（NO）和主要是非 T2 炎症相关。肥胖可能通过多种途径影响哮喘；气道和全身氧化应激被提出作为一种机制，可能可以解释肥胖引起的合并症增加和对治疗的反应不佳。很可能，氧化应激是由气道和全身代谢复杂变化驱动的非常多样化的一系列过程的继发现象。本文全面概述了肥胖和哮喘患者氧化应激的临床、代谢、病理生理和治疗方面。
