Zhao Weiwei, Zhang Zijia, Feng Xiangqing, Yang Jing, Du Haifeng
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
Org Lett. 2020 Aug 7;22(15):5850-5854. doi: 10.1021/acs.orglett.0c01930. Epub 2020 Jul 14.
A metal-free asymmetric transfer hydrogenation of unprotected indoles was successfully realized using a catalyst derived from HB(CF) and ()--butylsulfinamide with ammonia borane as a hydrogen source. A variety of indolines were achieved in 40-78% yields with up to 90% ee.
使用由HB(CF)和()-丁基亚磺酰胺衍生的催化剂，以硼烷氨作为氢源，成功实现了未保护吲哚的无金属不对称转移氢化反应。各种二氢吲哚的产率为40-78%，对映体过量率高达90%。
