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Fibroblast-activating factor production by interleukin (IL)-2 dependent T-cell clones from rheumatoid arthritis patients and normal donors.

作者信息

Ofosu-Appiah W A, Warrington R J, Wilkins J A

机构信息

Department of Immunology, University of Manitoba, Winnipeg, Canada.

出版信息

Rheumatol Int. 1988;8(5):219-24. doi: 10.1007/BF00269198.

DOI:10.1007/BF00269198
PMID:3266357
Abstract

T cells spontaneously responsive to interleukin (IL)-2 were cloned from the peripheral blood (PBL) or synovial fluid (SFL) lymphocyte populations obtained from patients with rheumatoid arthritis (RA) or from normal PBL. The clones were compared for their capacities to produce fibroblast-activating factors (FAFs) which support the growth of RA synovial fibroblasts. Clones derived from all sources produced FAFs following mitogen stimulation, but SFL clones synthesized significantly higher levels of FAF activity. Physicochemical characterization of the FAFs suggested that SFL- and PBL-derived clones produced similar factors. It was also demonstrated that interferon-gamma and IL-2 did not contribute to the FAF activity of the clone supernatants. These results demonstrate that a subpopulation of activated lymphocytes which are present in increased numbers in the rheumatoid joint can produce factors which influence rheumatoid synovial cell growth.

摘要

相似文献

1
Fibroblast-activating factor production by interleukin (IL)-2 dependent T-cell clones from rheumatoid arthritis patients and normal donors.
Rheumatol Int. 1988;8(5):219-24. doi: 10.1007/BF00269198.
2
Characterization of synovial T lymphocytes in rheumatoid arthritis. I. Production of IL-2 dependent T cell clones from synovial fluid and peripheral blood.类风湿关节炎中滑膜T淋巴细胞的特征。I. 从滑液和外周血中产生白细胞介素-2依赖的T细胞克隆。
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Quantitative absorption of interleukin-2 by peripheral blood and synovial fluid lymphocytes from patients with rheumatoid arthritis.
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本文引用的文献

1
Lymphokine modulation of fibroblast proliferation.
J Immunol. 1982 Mar;128(3):1484-6.
2
Ia+ T cells in synovial fluid and tissues of patients with rheumatoid arthritis.类风湿性关节炎患者滑液和组织中的Ia + T细胞。
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5
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.从人血中分离单核细胞和粒细胞。通过一次离心分离单核细胞，通过离心和1g沉降相结合的方法分离粒细胞。
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6
Spontaneous production of fibroblast-activating factor(s) by synovial inflammatory cells. A potential mechanism for enhanced tissue destruction.滑膜炎症细胞自发产生成纤维细胞激活因子。一种导致组织破坏加剧的潜在机制。
J Exp Med. 1985 Jan 1;161(1):210-22. doi: 10.1084/jem.161.1.210.
7
Increased proliferation of human synovial fibroblasts treated with recombinant immune interferon.用重组免疫干扰素处理的人滑膜成纤维细胞增殖增加。
J Immunol. 1985 May;134(5):3142-6.
8
The role of lymphokines and monokines in fibrosis.淋巴细胞因子和单核细胞因子在纤维化中的作用。
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Production of a fibroblast-stimulating factor by Schistosoma mansoni antigen-reactive T cell clones.曼氏血吸虫抗原反应性T细胞克隆产生成纤维细胞刺激因子。
J Immunol. 1986 Feb 1;136(3):1100-6.