Ege University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 35040 Bornova, Izmir, Turkey.
Int J Pharm. 2020 Sep 25;587:119588. doi: 10.1016/j.ijpharm.2020.119588. Epub 2020 Jul 11.
The main objectives of this work were to develop and characterize new 3D printing filaments and print them directly onto a packaging material. Different blends of polymers were tested to achieve low-temperature printing filaments, which are flexible and durable to be wound onto spools. The mechanical properties of filaments were compared with commercial filaments and evaluated by bending tests. Kollidon 12PF, PEG 4000, and PEO 900k blends resulted in promising filaments that could be extruded at 70 °C and had flexibility similar to commercial PLA filaments. Montelukast sodium (MS), which undergoes hepatic first-pass metabolism, was compounded into polymer blends, and drug-loaded filaments were extruded. All filaments were tested with a 3D printing pen prior to using with the 3D printer for transdermal patches. MS loaded filaments and patches showed similar flexibility with placebo. In vitro drug release studies showed 52% of MS was released in 24 h. Printing on disposable packaging material is presented for the first time with this study. Build plate adhesion and cohesion of 3D printed layers were successfully achieved. This new technique could prevent cross-contamination, save time, and provide ease of use, which can take us one step closer to the production of personalized drugs in pharmacies.
这项工作的主要目标是开发和表征新的 3D 打印线材，并直接将其打印到包装材料上。测试了不同的聚合物混合物以获得低温打印线材，这些线材具有柔韧性和耐用性，可以缠绕在卷轴上。通过弯曲试验比较了线材的机械性能，并与商业线材进行了评估。Kollidon 12PF、PEG 4000 和 PEO 900k 混合物产生了有前途的线材，这些线材可以在 70°C 下挤出，并且具有与商业 PLA 线材相似的柔韧性。孟鲁司特钠（MS）经历肝脏首过代谢，被掺入聚合物混合物中，并挤出载药线材。在使用 3D 打印机进行透皮贴片之前，所有线材都用 3D 打印笔进行了测试。载有 MS 的线材和贴片与安慰剂一样具有相似的柔韧性。体外药物释放研究表明，24 小时内释放了 52%的 MS。本研究首次在一次性包装材料上进行打印。成功实现了 3D 打印层的构建板附着力和内聚性。这项新技术可以防止交叉污染，节省时间，并提供易用性，这可以使我们更接近在药房生产个性化药物的目标。
