Chan Yong Li, Widodo Riyanto Teguh, Ming Long Chiau, Khan Abdullah, Abbas Syed Atif, Ping Ng Yen, Sofian Zarif Mohamed, Kanakal Mahibub Mahamadsa
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education (Deemed to be University), Sawangi (M), Wardha 442004, India.
Molecules. 2025 May 30;30(11):2411. doi: 10.3390/molecules30112411.
Three-dimensional printing, particularly Fused Deposition Modeling (FDM), has revolutionized dermatological drug delivery by offering the ability to create personalized and precise drug formulations. This technology enables the design of customized drug delivery systems using a variety of polymers, such as Polylactic Acid (PLA), Polyvinyl Alcohol (PVA), Polyethylene Glycol (PEG), and Polycaprolactone (PCL), each with unique properties that enhance drug release, patient compliance, and treatment efficacy. This review analyzes these polymers in terms of their advantages, limitations, and suitability for dermatological applications. The ability to tailor these materials offers significant potential in overcoming treatment regimens. Additionally, the customization of three-dimensional-printed drug delivery systems provides a platform for creating patient-specific solutions that are more effective and adaptable to individual needs. Despite challenges such as moisture sensitivity and mechanical brittleness, the potential of FDM technology to improve dermatological treatments remains promising. The future of three-dimensional printing in dermatology lies in the integration of optimized materials and advanced printing techniques, which could further enhance patient-specific care and broaden the clinical applicability of these technologies in the pharmaceutical and biomedical sectors. By addressing these limitations and expanding material choices, FDM-based drug delivery systems have the potential to revolutionize the management of dermatological conditions, offering improved therapeutic outcomes and quality of life for patients.
三维打印，尤其是熔融沉积建模（FDM），通过能够创建个性化且精确的药物制剂，彻底改变了皮肤科药物递送方式。这项技术能够使用多种聚合物设计定制化的药物递送系统，如聚乳酸（PLA）、聚乙烯醇（PVA）、聚乙二醇（PEG）和聚己内酯（PCL），每种聚合物都具有独特的特性，可增强药物释放、患者依从性和治疗效果。本综述从这些聚合物的优势、局限性以及在皮肤科应用的适用性方面进行了分析。定制这些材料的能力在克服治疗方案方面具有巨大潜力。此外，三维打印药物递送系统的定制为创建更有效且更能适应个体需求的患者特异性解决方案提供了一个平台。尽管存在诸如湿度敏感性和机械脆性等挑战，但FDM技术改善皮肤科治疗的潜力依然巨大。皮肤科三维打印的未来在于优化材料与先进打印技术的整合，这可能进一步加强患者特异性护理，并拓宽这些技术在制药和生物医学领域的临床应用范围。通过解决这些局限性并扩大材料选择范围，基于FDM的药物递送系统有潜力彻底改变皮肤科疾病的管理方式，为患者提供更好的治疗效果和生活质量。
