Xing Dong, Yang Zhaoxu, Cao Can, Dong Zhijie, Wei Jingchao, Zheng Xuehong, Li Wenyi
Department of Orthopedics, Hebei General Hospital, Shijiazhuang, China.
Medicine (Baltimore). 2020 Jul 10;99(28):e21148. doi: 10.1097/MD.0000000000021148.
Negative pressure wound therapy (NPWT) is an important therapy for the management of refractory wounds. The aim of this retrospective preliminary study was to introduce a modified NPWT (m-NPWT) and compared the efficacy of it with conventional NPWT (c-NPWT) in the management of refractory wounds.A total of 127 patients with refractory wounds receiving the NPWT from January 2010 to October 2017 in our hospital were retrospectively reviewed. The demographics and clinical data were collected from medical records and compared between m-NPWT group and c-NPWT group.There were 65 patients in c-NPWT group and 62 patients in m-NPWT group. No significant difference was observed between 2 groups in antimicrobial use (P = .51), hospitalization time (P = .24), wound-healing rate (P = .44) or complication rate (P = .59). However, patients in m-NPWT group had shorter wound-healing time (24.82 vs 27.66 days, P < .01), less debridement times (1.23 vs 2.08, P < .01), less total cost (3743.93 vs 6344.33 yuan, P < .01) and higher satisfaction rate (56/62 vs 44/65, P = .02) compared to those in c-NPWT group.The m-NPWT technique was an efficient and safe alternative therapy for refractory wounds.
负压伤口治疗（NPWT）是治疗难愈性伤口的一种重要方法。这项回顾性初步研究的目的是介绍一种改良的NPWT（m-NPWT），并比较其与传统NPWT（c-NPWT）在治疗难愈性伤口方面的疗效。对2010年1月至2017年10月在我院接受NPWT治疗的127例难愈性伤口患者进行回顾性分析。从病历中收集人口统计学和临床数据，并在m-NPWT组和c-NPWT组之间进行比较。c-NPWT组有65例患者，m-NPWT组有62例患者。两组在抗菌药物使用（P = 0.51）、住院时间（P = 0.24）、伤口愈合率（P = 0.44）或并发症发生率（P = 0.59）方面均无显著差异。然而，与c-NPWT组相比，m-NPWT组患者的伤口愈合时间更短（24.82天对27.66天，P < 0.01），清创次数更少（1.23次对2.08次，P < 0.01），总费用更低（3743.93元对6344.33元，P < 0.01），满意度更高（56/62对44/65，P = 0.02）。m-NPWT技术是治疗难愈性伤口的一种有效且安全的替代疗法。
