Niklas Arkadiusz, Marcinkowska Justyna, Kozela Magdalena, Pająk Andrzej, Zdrojewski Tomasz, Drygas Wojciech, Piwońska Aleksandra, Bielecki Wojciech, Kozakiewicz Krystyna, Tykarski Andrzej
Department of Hypertension, Angiology and Internal Disease.
Department of Computer Science and Statistics, University of Medical Science, Poznan.
Medicine (Baltimore). 2020 Jul 10;99(28):e21149. doi: 10.1097/MD.0000000000021149.
Hypertension is one of the most important causes of cardiovascular disease (CVD) incidence and mortality. The aim of the study was to assess the prevalence of metabolic syndrome and its individual components i.e., diabetes, obesity, elevated triglycerides (TG), low HDL (high-density lipoprotein) cholesterol, as well as selected manifestations of CVD i.e., atrial fibrillation (AF), peripheral artery disease (PAD), coronary artery disease (CAD), myocardial infarction (MI), and stroke in persons with and without hypertension in the Polish population.The analysis included participants of Polish multicentre WOBASZ II Study i.e., 6163 persons aged 19 and above. The Mantel Haenszel anlysis and multidimensional logistic regression model were used to assess the relations between the prevalence of metabolic syndrome and its individual components as well as selected manifestations of CVD with hypertension.Compared to normotensives, metabolic syndrome was over 5 times more prevalent in participants with hypertension (OR = 5.35, 95% CI:4.71-6.09). Components of the metabolic syndrome and selected manifestations of CVD were more prevalent in participants with hypertension compared to normotensives. The Mantel-Haenszel odds ratios (95% confidence intervals) were as follows: obesity counted as BMI > 30 kg/m OR = 2.58 (2.26-2.96), raised triglycerides OR = 2.34 (2.07-2.64), reduced HDL-C OR = 1.81 (1.59-2.06), metabolic syndrome OR = 5.35 (4.71-6.09), diabetes OR = 2.54 (1.98-3.26), AF OR = 1.47 (1.09-2.00), PAD OR = 1.51 (1.14-1.99), CAD OR = 1.94 (1.52-2.49), MI OR = 1.89 (1.32-2.70), hospitalization due to HF OR = 2.02 (1.43-2.87), hospitalization due to exacerbation of CAD OR = 2.13 (1.58-2.86), hospitalization due to revascularization OR = 2.38 (1.49-3.80), hospitalization due to stroke OR = 1.72 (1.1-2.68).Compared to normotensive participants, persons with hypertension had higher prevalence of diabetes, obesity, MS, PAD, CAD, stroke, MI and AF, and more frequent need for hospitalization due to HF, exacerbation of CAD and for coronary revascularization.
高血压是心血管疾病(CVD)发病和死亡的最重要原因之一。本研究的目的是评估波兰人群中患有和未患有高血压者的代谢综合征及其各个组分(即糖尿病、肥胖、甘油三酯(TG)升高、高密度脂蛋白(HDL)胆固醇降低)的患病率,以及CVD的某些表现(即心房颤动(AF)、外周动脉疾病(PAD)、冠状动脉疾病(CAD)、心肌梗死(MI)和中风)的患病率。分析纳入了波兰多中心WOBASZ II研究的参与者,即6163名19岁及以上的人群。采用Mantel Haenszel分析和多维度逻辑回归模型评估代谢综合征及其各个组分的患病率以及CVD的某些表现与高血压之间的关系。与血压正常者相比,高血压参与者的代谢综合征患病率高出5倍多(比值比(OR)=5.35,95%置信区间(CI):4.71 - 6.09)。与血压正常者相比,高血压参与者中代谢综合征的组分和CVD的某些表现更为常见。Mantel - Haenszel比值比(95%置信区间)如下:肥胖定义为体重指数(BMI)>30 kg/m²,OR = 2.58(2.26 - 2.96);甘油三酯升高,OR = 2.34(2.07 - 2.64);HDL - C降低,OR = 1.81(1.59 - 2.06);代谢综合征,OR = 5.35(4.71 - 6.09);糖尿病,OR = 2.54(1.98 - 3.26);AF,OR = 1.47(1.09 - 2.00);PAD,OR = 1.51(1.14 - 1.99);CAD,OR = 1.94(1.52 - 2.49);MI,OR = 1.89(1.32 - 2.70);因心力衰竭住院,OR = 2.02(1.43 - 2.87);因CAD加重住院,OR = 2.13(1.58 - 2.86);因血运重建住院,OR = 2.38(1.49 - 第3.80);因中风住院,OR = 1.72(1.1 - 2.68)。与血压正常的参与者相比,高血压患者的糖尿病、肥胖、代谢综合征、PAD、CAD、中风、MI和AF患病率更高,因心力衰竭、CAD加重和冠状动脉血运重建而住院的频率也更高。