Witkowska Anna Maria, Salem Joe-Elie
Department of Food Biotechnology, Faculty of Health Sciences, Medical University of Bialystok, Szpitalna 37, 15-295 Białystok, Poland.
Department of Pharmacology, Pitié-Salpêtrière Hospital, Institut National de la Santé et de la Recherche Médicale (INSERM), Clinical Investigation Center (CIC-1901), Assistance Publique-Hôpitaux de Paris (AP-HP), Sorbonne Université, 75013 Paris, France.
Biomolecules. 2023 Sep 2;13(9):1340. doi: 10.3390/biom13091340.
Cardiometabolic disorders are major causes of morbidity and mortality worldwide. A growing body of research indicates that the gut microbiota, whether it interacts favorably or not, plays an important role in host metabolism. Elucidating metabolic pathways may be crucial in preventing and treating cardiometabolic diseases, and omics methods are key to studying the interaction between the fecal microbiota and host metabolism. This review summarizes available studies that combine metabolomic and metagenomic approaches to describe the effects of drugs, diet, nutrients, and specific foods on cardiometabolic health and to identify potential targets for future research.
心脏代谢紊乱是全球发病和死亡的主要原因。越来越多的研究表明，肠道微生物群无论其相互作用是否有益，都在宿主代谢中发挥着重要作用。阐明代谢途径可能对预防和治疗心脏代谢疾病至关重要，而组学方法是研究粪便微生物群与宿主代谢之间相互作用的关键。本综述总结了现有的研究，这些研究结合代谢组学和宏基因组学方法来描述药物、饮食、营养素和特定食物对心脏代谢健康的影响，并确定未来研究的潜在靶点。
