丝氨酸蛋白酶抑制剂Kazal型5基因多态性与特应性皮炎风险：一项荟萃分析。
Genetic polymorphisms in serine protease inhibitor Kazal-type 5 and risk of atopic dermatitis: A meta-analysis.
作者信息
Li Yunling, Li Yin, Li Wei, Guo Xiaoxuan, Zhou Sha, Zheng Huiwen
机构信息
Department of Dermatology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, Zhejiang Province, China.
出版信息
Medicine (Baltimore). 2020 Jul 10;99(28):e21256. doi: 10.1097/MD.0000000000021256.
BACKGROUND
This study aimed to investigate the role of serine protease inhibitor Kazal-type 5 (SPINK5) polymorphisms (Asn368Ser, Asp386Asn and Glu420Lys) and the risk of atopic dermatitis (AD).
METHODS
Studies associated with SPINK5 mutations and AD risk were searched from three databases, including PubMed, Embase, and Cochrane library, with a retrieval deadline of April 22, 2019. An odds ratio (OR) with a 95% confidence interval (95% CI) was chosen as the effect size. Egger's linear regression test was enrolled to assess the level of publication bias.
RESULTS
Overall, 6 studies met the inclusion criteria for meta-analysis. Significantly statistical differences were calculated between patients with AD and healthy individuals on Asn368Ser polymorphism in the allele model (G vs A: OR = 1.2643, 95% CI = 1.0666-1.4987, P = .0069), co-dominant model (GG vs AA: OR = 1.6609, 95% CI = 1.1736-2.3505, P = .0042; GA vs AA: OR = 1.5448, 95% CI = 1.1263-2.1189, P = .0070), and dominant model (GG+GA vs AA: OR = 1.5700, 95% CI = 1.1656-2.1146, P = .0030). However, no statistically significant difference was found in the recessive model for Asn368Ser and other genetic models for Asp386Asn and Glu420Lys (all P > .05). No significant publication bias was found.
CONCLUSION
The SPINK5 Asn368Ser polymorphism may be a risk factor for AD.
背景
本研究旨在探讨丝氨酸蛋白酶抑制剂Kazal型5（SPINK5）基因多态性（Asn368Ser、Asp386Asn和Glu420Lys）与特应性皮炎（AD）风险之间的关系。
方法
从三个数据库（包括PubMed、Embase和Cochrane图书馆）检索与SPINK5突变和AD风险相关的研究，检索截止日期为2019年4月22日。选择比值比（OR）及其95%置信区间（95%CI）作为效应量。采用Egger线性回归检验评估发表偏倚水平。
结果
总体而言，6项研究符合荟萃分析的纳入标准。在等位基因模型中，AD患者与健康个体在Asn368Ser多态性方面存在显著统计学差异（G vs A：OR = 1.2643，95%CI = 1.0666 - 1.4987，P = 0.0069），共显性模型（GG vs AA：OR = 1.6609，95%CI = 1.1736 - 2.3505，P = 0.0042；GA vs AA：OR = 1.5448，95%CI = 1.1263 - 2.1189，P = 0.0070），显性模型（GG + GA vs AA：OR = 1.5700，95%CI = 1.1656 - 2.1146，P = 0.0030）。然而，在Asn368Ser的隐性模型以及Asp386Asn和Glu420Lys的其他遗传模型中未发现统计学显著差异（所有P > 0.05）。未发现显著的发表偏倚。
结论
SPINK5基因Asn368Ser多态性可能是AD的一个风险因素。
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