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癌症中的Rho家族GTP酶

Rho Family GTPases in Cancer.

作者信息

Dharmawardhane Suranganie

机构信息

Department of Biochemistry, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR 00936, USA.

出版信息

Cancers (Basel). 2021 Mar 12;13(6):1271. doi: 10.3390/cancers13061271.

DOI:10.3390/cancers13061271
PMID:33809395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7998900/
Abstract

This Special Issue containing seminal contributions from international experts highlights the current understanding of Rho GTPases in cancer, with an emphasis on recognizing their central importance as critical targets for cancer therapy and for chemosensitization of current therapeutic strategies [...].

摘要

本期特刊收录了国际专家的开创性贡献，突出了目前对Rho GTPases在癌症中的理解，重点是认识到它们作为癌症治疗关键靶点以及当前治疗策略化学增敏的核心重要性[...]。

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Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer.与由RHO GTP酶激活剂VAV2在增生性角质形成细胞和头颈癌中触发的干细胞样基因表达程序相关的药物易感性和疾病预后
Cancers (Basel). 2020 Sep 3;12(9):2498. doi: 10.3390/cancers12092498.
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Hormones Secretion and Rho GTPases in Neuroendocrine Tumors.神经内分泌肿瘤中的激素分泌与Rho GTP酶
Cancers (Basel). 2020 Jul 10;12(7):1859. doi: 10.3390/cancers12071859.
3
RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells.RAC1B通过USP26诱导SMAD7以抑制间充质亚型癌细胞中TGFβ1依赖性细胞迁移。
Cancers (Basel). 2020 Jun 11;12(6):1545. doi: 10.3390/cancers12061545.
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Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors.活性RAC1促进实体瘤的致瘤表型和治疗抗性。
Cancers (Basel). 2020 Jun 11;12(6):1541. doi: 10.3390/cancers12061541.
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Dysregulation of Rho GTPases in Human Cancers.人类癌症中Rho GTP酶的失调
Cancers (Basel). 2020 May 7;12(5):1179. doi: 10.3390/cancers12051179.
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MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.小Rho GTP酶调节因子的MicroRNA调控——靶向癌症转移中的复杂性与机遇
Cancers (Basel). 2020 Apr 28;12(5):1092. doi: 10.3390/cancers12051092.
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Cancers (Basel). 2020 Mar 12;12(3):665. doi: 10.3390/cancers12030665.
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P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer.前列腺癌中不依赖P-REX1的钙依赖性RAC1过度激活
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