Reis Zambom Carolina, Henrique da Fonseca Fauller, Santesso Garrido Saulo
Department of Biochemistry and Organic Chemistry, Institute of Chemistry, UNESP-Sao Paulo State University, Araraquara, SP 14800-060, Brazil.
Microorganisms. 2020 Jul 10;8(7):1024. doi: 10.3390/microorganisms8071024.
is a common microorganism of human's microbiota and can be easily found in both respiratory and gastrointestinal tracts as well as in the genitourinary tract. Approximately 30% of people will be infected by during their lifetime. Due to its easy adaptation, this microorganism started to present high resistance to antifungal agents which is associated with their indiscriminate use. There are several reports of adaptive mechanisms that this species can present. Some of them are intrinsic alteration in drug targets, secretion of extracellular enzymes to promote host protein degradation and efflux receptors that lead to a diminished action of common antifungal and host's innate immune response. The current review aims to bring promising alternatives for the treatment of candidiasis caused mainly by . One of these alternatives is the use of antifungal peptides (AFPs) from the Histatin family, like histatin-5. Besides that, our focus is to show how nanotechnology can allow the application of these peptides for treatment of this microorganism. In addition, our intention is to show the importance of nanoparticles (NPs) for this purpose, which may be essential in the near future.
是人类微生物群中的常见微生物，在呼吸道、胃肠道以及泌尿生殖道中都很容易发现。大约30%的人在一生中会受到感染。由于其易于适应，这种微生物开始对抗真菌药物表现出高度耐药性，这与药物的滥用有关。有几篇关于该物种可能出现的适应性机制的报道。其中一些是药物靶点的内在改变、分泌细胞外酶以促进宿主蛋白降解以及外排受体，这些导致常见抗真菌药物的作用减弱和宿主的先天免疫反应。本综述旨在为主要由引起的念珠菌病治疗带来有前景的替代方法。其中一种替代方法是使用组蛋白家族的抗真菌肽（AFP），如组蛋白-5。除此之外，我们的重点是展示纳米技术如何使这些肽应用于该微生物的治疗。此外，我们的目的是表明纳米颗粒（NP）在此方面的重要性，这在不久的将来可能至关重要。
