Sharma Pratibha, Chaudhary Mehak, Khanna Garima, Rishi Praveen, Kaur Indu Pal
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
Department of Microbiology, Panjab University, Chandigarh 160014, India.
J Fungi (Basel). 2021 Dec 12;7(12):1070. doi: 10.3390/jof7121070.
Fungi are reported to cause a range of superficial to invasive human infections. These often result in high morbidity and at times mortality. Conventional antifungal agents though effective invariably exhibit drug interactions, treatment-related toxicity, and fail to elicit significant effect, thus indicating a need to look for suitable alternatives. Fungi thrive in humid, nutrient-enriched areas. Such an environment is well-supported by the oral cavity. Despite this, there is a relatively low incidence of severe oral and periodontal fungal infections, attributed to the presence of antimicrobial peptides hosted by saliva, viz. histatin 5 (Hstn 5). It displays fungicidal activity against a variety of fungi including , and unicellular yeast-like . alone accounts for about 70% of all global fungal infections including periodontal disease. This review intends to discuss the scope of Hstn 5 as a novel recourse for the control of fungal infections.
据报道，真菌可引起一系列从浅表到侵袭性的人类感染。这些感染常常导致高发病率，有时甚至导致死亡。传统抗真菌药物虽然有效，但总是会出现药物相互作用、治疗相关毒性，且未能产生显著效果，因此表明需要寻找合适的替代药物。真菌在潮湿、营养丰富的区域生长旺盛。口腔环境为这种环境提供了良好的支持。尽管如此，严重的口腔和牙周真菌感染的发病率相对较低，这归因于唾液中存在抗菌肽，即组蛋白5（Hstn 5）。它对包括 以及单细胞酵母样 在内的多种真菌具有杀真菌活性。 单独就占包括牙周病在内的所有全球真菌感染的约70%。本综述旨在讨论Hstn 5作为控制真菌感染的新手段的应用范围。
