Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
Viruses. 2020 Jul 10;12(7):744. doi: 10.3390/v12070744.
Human papillomaviruses are the causative agents of cervical and other anogenital cancers along with approximately 60% of oropharyngeal cancers. These small double-stranded DNA viruses infect stratified epithelia and link their productive life cycles to differentiation. HPV proteins target cellular factors, such as those involved in DNA damage repair, as well as epigenetic control of host and viral transcription to regulate the productive life cycle. HPVs constitutively activate the ATM and ATR DNA repair pathways and preferentially recruit these proteins to viral genomes to facilitate productive viral replication. In addition, the sirtuin deacetylases along with histone acetyltransferases, including Tip60, are targeted in HPV infections to regulate viral transcription and replication. These pathways provide potential targets for drug therapy to treat HPV-induced disease.
人乳头瘤病毒是导致宫颈癌和其他肛门生殖器癌症的病原体，约占口咽癌的 60%。这些小型双链 DNA 病毒感染分层上皮组织，并将其有性生命周期与分化联系起来。HPV 蛋白靶向细胞因子，如参与 DNA 损伤修复的细胞因子，以及宿主和病毒转录的表观遗传控制，以调节有性生命周期。HPV 持续激活 ATM 和 ATR 修复途径，并优先将这些蛋白募集到病毒基因组上，以促进病毒的复制。此外，在 HPV 感染中，组蛋白去乙酰化酶，包括 Tip60，以及组蛋白乙酰转移酶，都被靶向以调节病毒转录和复制。这些途径为治疗 HPV 引起的疾病提供了潜在的药物治疗靶点。
