Department of Genetics, Maharshi Dayanand University, Rohtak, Haryana, 124001, India.
Mol Biol Rep. 2024 Jun 14;51(1):743. doi: 10.1007/s11033-024-09680-6.
Human papillomavirus (HPV), a common cause of sexually transmitted diseases, may cause warts and lead to various types of cancers, which makes it important to understand the risk factors associated with it. HPV is the leading risk factor and plays a crucial role in the progression of cervical cancer. Viral oncoproteins E6 and E7 play a pivotal role in this process. Beyond cervical cancer, HPV-associated cancers of the mouth and throat are also increasing. HPV can also contribute to other malignancies like penile, vulvar, and vaginal cancers. Emerging evidence links HPV to these cancers. Research on the oncogenic effect of HPV is still ongoing and explorations of screening techniques, vaccination, immunotherapy and targeted therapeutics are all in progress. The present review offers valuable insight into the current understanding of the role of HPV in cancer and its potential implications for treatment and prevention in the future.
人乳头瘤病毒（HPV）是一种常见的性传播疾病病原体，可能引起疣，并导致各种类型的癌症，因此了解其相关风险因素非常重要。HPV 是主要的危险因素，在宫颈癌的进展中起着关键作用。病毒癌蛋白 E6 和 E7 在这个过程中起着关键作用。除了宫颈癌，与 HPV 相关的口腔和咽喉癌也在增加。HPV 还可能导致其他恶性肿瘤，如阴茎癌、外阴癌和阴道癌。新出现的证据将 HPV 与这些癌症联系起来。关于 HPV 致癌作用的研究仍在进行中，筛查技术、疫苗接种、免疫疗法和靶向治疗的探索也在进行中。本综述为人们提供了对 HPV 在癌症中的作用及其对未来治疗和预防的潜在影响的当前认识的有价值的见解。
