Montag T, Tietz H J, Widera P, Malikov W E, Mann W, Liebenthal C, Gantenberg R, Pfeiffer E
Department of Medical Microbiology, Medical Faculty (Charité), Humboldt University, Berlin, GDR.
Biomed Biochim Acta. 1988;47(6):537-42.
Brucella melitensis attaches selectively to B lymphocytes. The bacterium induces in vitro only a slight proliferation of mononuclear cells and inhibits the spontaneous IgG synthesis. In order to characterize these effects, the O-chain of the lipopolysaccharide of Brucella melitensis (a polysaccharide consisting of poly-4,6-dideoxy-4-formamido-alpha-D-mannoside) was prepared and its influence on lymphocyte functions tested. This compound had no effect on blast transformation whereas IgG synthesis of the cells was stimulated more than tenfold by the addition of the Brucella polymannoside.
羊种布鲁氏菌选择性地附着于B淋巴细胞。该细菌在体外仅诱导单核细胞轻微增殖，并抑制自发的IgG合成。为了表征这些效应，制备了羊种布鲁氏菌脂多糖的O链（一种由聚-4,6-二脱氧-4-甲酰胺基-α-D-甘露糖苷组成的多糖），并测试了其对淋巴细胞功能的影响。该化合物对母细胞转化没有影响，而添加布鲁氏菌多聚甘露糖苷后，细胞的IgG合成被刺激了十多倍。
