Layfield L J, Bhuta S
Department of Pathology, UCLA School of Medicine 90024.
Diagn Cytopathol. 1988;4(2):140-3. doi: 10.1002/dc.2840040213.
The cytologic features of a case of histiocytosis X diagnosed by fine-needle aspiration biopsy of a right cervical lymph node in a 15-mo-old girl are reported. Characteristic reticuloendothelial cells with abundant cytoplasm and grooved nuclei were observed. Electron microscopy of the aspiration-derived specimen revealed Birbeck granules. The cytologic pattern and electron microscopic demonstration of Birbeck granules allowed definite diagnosis of lymph node involvement by histiocytosis X, negating the need for open biopsy. The cytologic differential diagnosis and current diagnostic criteria for histiocytosis X are discussed.
报告了一名15个月大女孩右颈淋巴结细针穿刺活检诊断为组织细胞增多症X的病例的细胞学特征。观察到具有丰富细胞质和沟状核的特征性网状内皮细胞。对穿刺获得的标本进行电子显微镜检查发现了Birbeck颗粒。Birbeck颗粒的细胞学模式和电子显微镜显示使得能够明确诊断组织细胞增多症X累及淋巴结，从而无需进行开放性活检。文中讨论了组织细胞增多症X的细胞学鉴别诊断和当前诊断标准。
