Akhtar M, Ali M A, Bakry M, Sackey K, Sabbah R
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Diagn Cytopathol. 1993 Oct;9(5):527-33. doi: 10.1002/dc.2840090511.
A series of 14 fine-needle aspiration biopsies (FNAB) from histologically proven cases of histiocytosis-x (Hx) were reviewed. The smears revealed a variable mixture of Langerhans cells, eosinophils, macrophages, polymorphonuclear cells, and giant cells. Based on the predominant cells present, the cases were further categorized as Langerhans cell predominant (nine cases), eosinophil predominant (two cases), and macrophage predominant (three cases). Langerhans cells were usually polygonal without significant evidence of phagocytosis and frequently contained indented nuclei. In three cases, several Langerhans cells showed prominent dendritic processes. Electron microscopy in 10 cases revealed Langerhans cells with varying degrees of morphologic differentiation. All cases studied revealed Birbeck granules. These findings indicate that FNAB may be an effective technique for diagnosing Hx.
回顾了一系列来自组织学确诊的组织细胞增多症X（Hx）病例的14次细针穿刺活检（FNAB）。涂片显示朗格汉斯细胞、嗜酸性粒细胞、巨噬细胞、多形核细胞和巨细胞的混合情况各不相同。根据主要存在的细胞，这些病例进一步分为朗格汉斯细胞为主型（9例）、嗜酸性粒细胞为主型（2例）和巨噬细胞为主型（3例）。朗格汉斯细胞通常呈多边形，无明显吞噬迹象，且细胞核常呈凹陷状。在3例中，数个朗格汉斯细胞显示出明显的树突状突起。10例的电子显微镜检查显示朗格汉斯细胞有不同程度的形态分化。所有研究病例均发现了伯贝克颗粒。这些发现表明FNAB可能是诊断Hx的一种有效技术。
