脑池内注射促肾上腺皮质激素释放因子拮抗剂可阻断手术应激诱导的大鼠胃分泌抑制。
Intracisternal injection of CRF antagonist blocks surgical stress-induced inhibition of gastric secretion in the rat.
作者信息
Stephens R L, Yang H, Rivier J, Taché Y
机构信息
Center for Ulcer Research and Education, Veterans' Administration Medical Center, CA.
出版信息
Peptides. 1988 Sep-Oct;9(5):1067-70. doi: 10.1016/0196-9781(88)90090-3.
The effects of intracisternal injection of CRF antagonist, alpha-CRF 9-41, on the inhibition of gastric acid secretion elicited by intracisternal injection of corticotropin-releasing factor (CRF) and stress were investigated in conscious pylorus-ligated rats. Intracisternal injection of the alpha-helical CRF 9-41 (50 micrograms) did not influence basal gastric secretion, but injected concomitantly with intracisternal CRF (5 micrograms), completely blocked CRF (5 micrograms)-induced inhibition of gastric secretory volume, acid concentration and output. Intracisternal injection of alpha-helical CRF 9-41 (3, 10, 50 micrograms) produced a dose-related reversal (0, 52 and 100%) of brain surgery-induced inhibition of gastric acid output. By contrast intravenous injection of CRF antagonist (50 micrograms) did not inhibit gastric hyposecretory response to brain surgery. These data suggest that endogenous CRF in the brain may mediate stress-induced gastric hyposecretion in the rat.
在清醒的幽门结扎大鼠中，研究了脑池内注射促肾上腺皮质激素释放因子（CRF）拮抗剂α-CRF 9-41对脑池内注射促肾上腺皮质激素释放因子（CRF）和应激引起的胃酸分泌抑制的影响。脑池内注射α-螺旋CRF 9-41（50微克）不影响基础胃酸分泌，但与脑池内注射CRF（5微克）同时注射时，完全阻断了CRF（5微克）诱导的胃酸分泌量、酸浓度和输出量的抑制。脑池内注射α-螺旋CRF 9-41（3、10、50微克）产生了与剂量相关的脑手术诱导的胃酸分泌抑制的逆转（0%、52%和100%）。相比之下，静脉注射CRF拮抗剂（50微克）不抑制对脑手术的胃酸分泌减少反应。这些数据表明，大脑中的内源性CRF可能介导大鼠应激诱导的胃酸分泌减少。
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