Dryllis Georgios, Liakou Panagiota, Politou Marianna
Hematology Laboratory-Blood Bank, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens 11528, Greece, Athens, Greece.
Folia Med (Plovdiv). 2020 Jun 30;62(2):230-237. doi: 10.3897/folmed.62.e47831.
Pregnancy short- or long-term complications may involve the mother's health, the fetus's health, or both. A systematic literature review was performed, including studies up to October 2018 from Medline (PubMed), Science Direct, Web of Science and Google Scholar. The following inclusion criteria were applied: studies published until 2018 concerning the genetic background of pregnancy complications such as high blood pressure, gestational diabetes, preeclampsia, pregnancy loss, endometrial death, placental abruption, premature labor, and intrauterine growth retardation which may render pregnancy a high risk condition.We identified 164 articles that met the inclusion criteria and reviewed and analyzed them. The results so far are contradictory and the pathogenicity of these pregnancy complications remains unclear. For most of the polymorphisms studied so far, data refer to small studies size but research is on-going.The identification of genetic polymorphisms with strong correlations with certain pregnancy complications could provide us with useful tools which could be incorporated in diagnostic algorithms that could facilitate early detection and treatment of major pregnancy complications.
妊娠的短期或长期并发症可能涉及母亲的健康、胎儿的健康或两者。我们进行了一项系统的文献综述，纳入了截至2018年10月来自Medline（PubMed）、Science Direct、Web of Science和谷歌学术的研究。应用了以下纳入标准：截至2018年发表的关于妊娠并发症遗传背景的研究，这些并发症包括高血压、妊娠期糖尿病、先兆子痫、妊娠丢失、子宫内膜死亡、胎盘早剥、早产和宫内生长受限，这些可能使妊娠成为高危情况。我们确定了164篇符合纳入标准的文章并对其进行了综述和分析。目前的结果相互矛盾，这些妊娠并发症的致病性仍不清楚。对于迄今为止研究的大多数多态性，数据来自样本量较小的研究，但研究仍在进行中。确定与某些妊娠并发症有强相关性的基因多态性可以为我们提供有用的工具，这些工具可纳入诊断算法，以促进主要妊娠并发症的早期检测和治疗。
