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多臂试验中不同处理组不进行多重检验：原理与理由。

Non-adjustment for multiple testing in multi-arm trials of distinct treatments: Rationale and justification.

机构信息

Edinburgh Clinical Trials Unit, Usher Institute, The University of Edinburgh, Edinburgh, UK.

出版信息

Clin Trials. 2020 Oct;17(5):562-566. doi: 10.1177/1740774520941419. Epub 2020 Jul 15.

DOI:10.1177/1740774520941419
PMID:32666813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7534018/
Abstract

There is currently a lack of consensus and uncertainty about whether one should adjust for multiple testing in multi-arm trials of distinct treatments. A detailed rationale is presented to justify non-adjustment in this situation. We argue that non-adjustment should be the default starting position in simple multi-arm trials of distinct treatments.

摘要

目前，对于是否应该在不同治疗方法的多臂试验中进行多次检验调整，尚未达成共识且存在不确定性。本文提出了详细的基本原理来证明在这种情况下不进行调整是合理的。我们认为，在简单的不同治疗方法的多臂试验中，不进行调整应该是默认的起始立场。

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