Abe Y, Miyake M, Sagawa T, Kimura S
Second Department of Surgery, Ehime University School of Medicine, Japan.
Jpn J Surg. 1988 Nov;18(6):641-6. doi: 10.1007/BF02471524.
In order to investigate the contribution of growth factors in conditions of postoperative stress, we measured the blood and urine hEGF levels in patients with various surgical disorders. While the levels of serum and plasma hEGF did not change significantly after surgery, urine hEGF (u-hEGF) stayed at the base-level followed by a single peak within a postoperative period of two weeks. The peak day of u-hEGF in patients with more than 1000 ml of intraoperative bleeding was later than that in patients with bleeding of less than 1000 ml. In patients with postoperative renal failure or dysfunction, u-hEGF levels dropped and did not rise until the recovery of renal function. The changing pattern of u-hEGF levels was an indicator of operative bleeding volume and renal function.
为了研究生长因子在术后应激状态下的作用，我们测量了患有各种外科疾病患者的血液和尿液中人表皮生长因子（hEGF）水平。虽然血清和血浆hEGF水平在手术后没有显著变化，但尿液hEGF（u-hEGF）在术后两周内保持在基础水平，随后出现一个峰值。术中出血超过1000毫升的患者u-hEGF的峰值出现时间晚于出血少于1000毫升的患者。在术后肾衰竭或功能障碍的患者中，u-hEGF水平下降，直到肾功能恢复才上升。u-hEGF水平的变化模式是手术出血量和肾功能的一个指标。
