Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Institute of Inorganic Chemistry I, Ulm University, Albert-Einstein-Allee 11, 89081, Ulm, Germany.
ChemMedChem. 2021 Jan 8;16(1):94-104. doi: 10.1002/cmdc.202000412. Epub 2020 Aug 13.
Proteins have attracted increasing attention as biopharmaceutics and diagnostics due to their high specificity, biocompatibility, and biodegradability. The biopharmaceutical sector in particular is experiencing rapid growth, which has led to an increase in the production and sale of protein drugs and diagnostics over the last two decades. Since the first-generation biopharmaceutics dominated by native proteins, both recombinant and chemical technologies have evolved and transformed the outlook of this rapidly developing field. This review article presents updates on the fabrication of covalent and supramolecular fusion hybrids, as well as protein-polymer hybrids using solid-phase approaches that hold great promise for preparing protein hybrids with precise control at the macromolecular level to incorporate additional features. In addition, the applications of the resultant protein hybrids in medicine and diagnostics are highlighted where possible.
由于其高特异性、生物相容性和可生物降解性，蛋白质作为生物制药和诊断试剂越来越受到关注。特别是生物制药领域正在经历快速增长，这导致在过去二十年中，蛋白质药物和诊断试剂的生产和销售都有所增加。自从第一代以天然蛋白质为主导的生物制药出现以来，重组和化学技术都得到了发展，并改变了这个快速发展领域的前景。本文综述了利用固相方法制备共价和超分子融合杂合体以及蛋白质-聚合物杂合体的最新进展，这些方法在制备具有精确大分子水平控制的蛋白质杂合体方面具有很大的潜力，可以引入额外的功能。此外，还尽可能突出了所得蛋白质杂合体在医学和诊断中的应用。
