Mu Fangxiang, Rusip Gusbakti, Florenly Florenly
University Prima Indonesia Medan Sumatera Utara Indonesia.
FASEB Bioadv. 2024 Sep 21;6(11):467-476. doi: 10.1096/fba.2024-00037. eCollection 2024 Nov.
In recent years, the scientific community has shown interest in the role of gut microbiota in the development of autoimmune diseases (AID). Although observational studies have revealed significant associations between gut microbiota and AID like rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, these connections do not necessarily imply causality. Mendelian randomization (MR) approach has been extensively employed to investigate the causal relationship. Relevant MR study findings indicate that a reduction in beneficial microbial populations, particularly and , and an increase in potential pathogenic microbes, is correlated with an elevated AID risk. Given the innovative potential of MR in unraveling the etiopathogenesis of AIDs, this article offers an overview of this methodological approach and its recent applications in AID research.
近年来，科学界对肠道微生物群在自身免疫性疾病（AID）发展中的作用表现出兴趣。尽管观察性研究已经揭示了肠道微生物群与类风湿性关节炎、系统性红斑狼疮和多发性硬化症等自身免疫性疾病之间的显著关联，但这些联系并不一定意味着因果关系。孟德尔随机化（MR）方法已被广泛用于研究因果关系。相关的孟德尔随机化研究结果表明，有益微生物种群的减少，特别是[具体微生物名称1]和[具体微生物名称2]，以及潜在致病微生物的增加，与自身免疫性疾病风险的升高相关。鉴于孟德尔随机化在揭示自身免疫性疾病病因发病机制方面的创新潜力，本文概述了这种方法及其在自身免疫性疾病研究中的最新应用。
