免疫疗法治疗伴有淋巴样基质的胃癌：一例报告
Treatment of gastric carcinoma with lymphoid stroma by immunotherapy: A case report.
作者信息
Cui Yu-Jie, Ren Yan-Yan, Zhang Hong-Zhen
机构信息
Department of Oncology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, China.
Department of Medicine, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
出版信息
World J Clin Cases. 2022 Sep 6;10(25):8962-8967. doi: 10.12998/wjcc.v10.i25.8962.
BACKGROUND
Gastric cancer with lymphoid stroma (GCLS) is a rare type of gastric cancer characterized by abundant lymphocytic infiltration of the stroma. It is an Epstein-Barr virus-associated gastric cancer with a better prognosis than typical gastric cancer but with similar symptoms. GCLS diagnosis is based on pathological, histological and immunohistochemical examination and there are no standardized guidelines for treatment.
CASE SUMMARY
This case report describes a 72-year-old man with a 6-mo history of abdominal pain. Endoscopy revealed ulcerative lesions in the stomach and gastric cancer was suspected. A preoperative endoscopic biopsy indicated undifferentiated carcinoma and postoperative pathological, histological and immunohistochemical analyses of the resected specimen confirmed a final diagnosis of GCLS.
CONCLUSION
The patient showed high programmed cell death-ligand 1 expression and recovered well after immunotherapy.
背景
伴有淋巴样间质的胃癌（GCLS）是一种罕见的胃癌类型，其特征为间质中有大量淋巴细胞浸润。它是一种与爱泼斯坦-巴尔病毒相关的胃癌，预后比典型胃癌好，但症状相似。GCLS的诊断基于病理、组织学和免疫组化检查，且尚无标准化的治疗指南。
病例摘要
本病例报告描述了一名72岁男性，有6个月的腹痛病史。内镜检查发现胃内有溃疡性病变，怀疑为胃癌。术前内镜活检显示为未分化癌，切除标本的术后病理、组织学和免疫组化分析最终确诊为GCLS。
结论
该患者程序性细胞死亡配体1表达较高，免疫治疗后恢复良好。
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