微卫星高度不稳定和爱泼斯坦-巴尔病毒阳性胃癌的亚组及其与新型免疫疗法的关联
MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy.
作者信息
Rodriquenz Maria Grazia, Roviello Giandomenico, D'Angelo Alberto, Lavacchi Daniele, Roviello Franco, Polom Karol
机构信息
Division of Medical Oncology, Department of Onco-Hematology, IRCCS-CROB, Referral Cancer Center of Basilicata, via Padre Pio 1, 85028 Rionero, Vulture (PZ), Italy.
Department of Health Sciences, University of Florence, viale Pieraccini, 6, 50139 Florence, Italy.
出版信息
J Clin Med. 2020 May 11;9(5):1427. doi: 10.3390/jcm9051427.
Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.
胃癌在历史上一直是根据组织形态学特征进行分类的。癌症基因组图谱网络报告了与胃癌相关的基因改变的全面鉴定，确定了四种不同的亚型——爱泼斯坦-巴尔病毒（EBV）阳性、微卫星不稳定/错配修复缺陷（MSI）、基因组稳定和染色体不稳定。特别是，EBV阳性和MSI胃癌似乎对新型免疫治疗药物有反应。这篇综述的目的是描述MSI和EBV阳性胃癌的亚组及其与新型免疫治疗的关系。
Zotero 插件