Croitoru Catalin, Roata Ionut Claudiu, Pascu Alexandru, Stanciu Elena Manuela
Materials Engineering and Welding Department, Transilvania University of Brasov, Eroilor 29 Str, 500036 Brasov, Romania.
Polymers (Basel). 2020 Jul 13;12(7):1544. doi: 10.3390/polym12071544.
This paper reports the obtaining of poly (vinyl alcohol) and i-carrageenan blend hydrogels by physical crosslinking (consecutive freeze-thaw cycles). The two polymers were completely miscible in the weight ratio interval used in this study, as determined by solution viscometry data. Strong interactions through hydrogen bonding and forming of mixed interpolymer crystalline domains were observed, which are responsible for the formation of stable drug release-tunable matrices. The release profiles of three model antibiotic drugs (amoxicillin, tetracycline hydrochloride, and gentamicin sulfate) were assessed in a pH interval between 3 and 7.3. They were found to be strongly dependent on the drug chemistry, mesh size of the hydrogels, swelling mechanism, and pH of the release medium. A decrease of up to 40% in the release rates and up to 10% in the diffusion coefficients of the model drugs was registered with the increase in i-carrageenan content.
本文报道了通过物理交联（连续冻融循环）获得聚乙烯醇与ι-卡拉胶共混水凝胶的方法。通过溶液粘度测定数据确定，在本研究使用的重量比范围内，这两种聚合物完全互溶。观察到通过氢键形成的强相互作用以及混合聚合物结晶域的形成，这是形成稳定的药物释放可调基质的原因。在pH值介于3和7.3之间的区间内评估了三种模型抗生素药物（阿莫西林、盐酸四环素和硫酸庆大霉素）的释放曲线。发现它们强烈依赖于药物化学性质、水凝胶的网孔尺寸、溶胀机制以及释放介质的pH值。随着ι-卡拉胶含量的增加，模型药物的释放速率降低了多达40%，扩散系数降低了多达10%。
