Tolu E, Mameli O, Caria M A, Melis F
Institute of Human Physiology, University of Sassari, Italy.
Acta Otolaryngol Suppl. 1988;460:72-9. doi: 10.3109/00016488809125138.
The influence of flunarizine on vestibular compensation was investigated in hemilabyrinthectomized guinea pigs. The results showed that the vestibular deficits from hemilabyrinthectomy disappeared more rapidly in the treated animals than in the controls. To elucidate the mechanism by which the drug could affect the compensatory process, further studies on the spontaneous and evoked activity of vestibular nuclei were performed in normal, labyrinthectomized and labyrinthectomized-cerebellectomized animals. These electrophysiological data implied that flunarizine improved the vestibular compensation by inhibiting the receptor and nuclear activities of the intact labyrinth. The drug excited the cerebellar cortex, which modulated the activity of the vestibular nuclei of both sides, restoring the balance disrupted by hemilabyrinthectomy.
研究了氟桂利嗪对半规管切除的豚鼠前庭代偿的影响。结果表明，与对照组相比，治疗组动物半规管切除引起的前庭功能缺损消失得更快。为阐明该药物影响代偿过程的机制，对正常、半规管切除及半规管切除-小脑切除的动物进行了关于前庭核自发活动和诱发性活动的进一步研究。这些电生理数据表明，氟桂利嗪通过抑制完整迷路的感受器和核活动来改善前庭代偿。该药物兴奋小脑皮质，从而调节双侧前庭核的活动，恢复因半规管切除而破坏的平衡。
