Rezai H R, Behbehani A B, Gettner S, Ardehali S
Department of Microbiology, Medical School, Shiraz University, Iran.
Ann Trop Med Parasitol. 1988 Jun;82(3):243-9. doi: 10.1080/00034983.1988.11812239.
The effects of levamisole on the course of Leishmania enriettii infection in guinea-pigs and L. major in mice were investigated. It was demonstrated that levamisole-treated guinea-pigs either did not develop an ulcerative lesion or developed a much smaller lesion than untreated animals. Moreover, metastases which are commonly produced in approximately 50% of animals receiving 2 x 10(6) L. enriettii did not occur in levamisole-treated guinea-pigs. Leishmania enriettii infection usually causes leukopenia and eosinophilia in guinea-pigs approximately two to three weeks after infection. These haematological changes did not occur in animals receiving levamisole. The percentage of rosette T-cells which diminished in the L. enriettii infection was normalized in the group of levamisole-treated and infected guinea-pigs. The severity of Leishmania infection in mice receiving levamisole was lower in comparison to a control group of the animals.
研究了左旋咪唑对豚鼠感染恩氏利什曼原虫以及对小鼠感染硕大利什曼原虫病程的影响。结果表明，经左旋咪唑处理的豚鼠要么未出现溃疡性病变，要么出现的病变比未处理的动物小得多。此外，在接受2×10⁶个恩氏利什曼原虫的动物中，约50%通常会产生转移灶，而经左旋咪唑处理的豚鼠未出现这种情况。恩氏利什曼原虫感染通常在豚鼠感染后约两到三周引起白细胞减少和嗜酸性粒细胞增多。接受左旋咪唑的动物未出现这些血液学变化。在经左旋咪唑处理并感染的豚鼠组中，恩氏利什曼原虫感染时减少的玫瑰花结T细胞百分比恢复正常。与动物对照组相比，接受左旋咪唑的小鼠利什曼原虫感染严重程度较低。
