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肥厚型心肌病——现实世界中一种异质性和终身性疾病。

Hypertrophic Cardiomyopathy - A Heterogeneous and Lifelong Disease in the Real World.

机构信息

Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University.

Cardiomyopathy Institute, Chikamori Hospital.

出版信息

Circ J. 2020 Jul 22;84(8):1218-1226. doi: 10.1253/circj.CJ-20-0524. Epub 2020 Jul 14.

Abstract

Hypertrophic cardiomyopathy (HCM) is the most frequent hereditary cardiomyopathy, showing an autosomal-dominant f inheritance. A great deal of attention has been paid to genetics, left ventricular tract obstruction and the prediction and prevention of sudden cardiac death in HCM. Needless to say, these are very important, but we should recognize the heterogeneity in etiology, morphology, clinical course and management of this unique cardiomyopathy. Another important perspective is that HCM causes left ventricular remodeling over time and is a disease that requires lifelong management in the real world.

摘要

肥厚型心肌病(HCM)是最常见的遗传性心肌病,呈常染色体显性遗传。人们对 HCM 的遗传学、左心室流出道梗阻以及心源性猝死的预测和预防给予了极大关注。毋庸置疑,这些非常重要,但我们也应该认识到这种独特心肌病在病因、形态、临床病程和管理方面的异质性。另一个重要的观点是,HCM 会导致左心室重构随时间推移而发生,在现实世界中,它是一种需要终身管理的疾病。

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