Zhou Xianpeng, Wang Hao, Yan Biao, Nie Xinwen, Chen Qingjie, Yang Xiaosong, Lei Min, Guo Xiying, Ouyang Changhan, Ren Zhanhong
Hubei University of Science and Technology, Xianning, 437100, Hubei, People's Republic of China.
Cardiovasc Drugs Ther. 2024 Dec 6. doi: 10.1007/s10557-024-07642-5.
Cardiovascular diseases (CVDs) are major public health problems that threaten the lives and health of individuals. The article has reviewed recent progresses about ferroptosis and ferroptosis-related intervention approaches for the treatment of CVDs and provided more references and strategies for targeting ferroptosis to prevent and treat CVDs.
A comprehensive review was conducted using the literature researches.
Many ferroptosis-targeted compounds and ferroptosis-related genes may be prospective targets for treating CVDs and our review provides a solid foundation for further studies about the detailed pathological mechanisms of CVDs.
There are challenges and limitations about the translation of ferroptosis-targeted potential therapies from experimental research to clinical practice. It warrants further exploration to pursure safer and more effective ferroptosis-targeted thereapeutic approaches for CVDs.
心血管疾病（CVDs）是威胁个人生命和健康的主要公共卫生问题。本文综述了近年来铁死亡及铁死亡相关干预方法在心血管疾病治疗中的研究进展，为靶向铁死亡防治心血管疾病提供更多参考和策略。
通过文献研究进行全面综述。
许多靶向铁死亡的化合物和铁死亡相关基因可能是治疗心血管疾病的潜在靶点，我们的综述为进一步研究心血管疾病详细病理机制奠定了坚实基础。
将靶向铁死亡的潜在疗法从实验研究转化为临床实践存在挑战和局限性。有必要进一步探索更安全、有效的靶向铁死亡治疗心血管疾病的方法。
