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长期质子泵抑制剂治疗致高胃泌素血症引起的 Wernicke-Korsakoff 综合征。

Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors.

机构信息

Department of Neurology, School of Medicine, Sapporo Medical University, Japan.

Department of Orthopedics, Chitose City Hospital, Japan.

出版信息

Intern Med. 2020 Nov 1;59(21):2783-2787. doi: 10.2169/internalmedicine.5168-20. Epub 2020 Jul 14.

DOI:10.2169/internalmedicine.5168-20
PMID:32669503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7691029/
Abstract

We herein report a patient with Wernicke-Korsakoff syndrome (WKS) who had neither a history of alcoholism or of history of gastric surgery. A 56-year-old woman was transferred to our hospital because of the loss of consciousness and she was diagnosed to have Wernicke encephalopathy. She showed proton pump inhibitor-induced refractory hypergastrinemia with the subsequent development of hyperemesis and a vitamin B1 deficiency.

摘要

我们在此报告一例 Wernicke-Korsakoff 综合征（WKS）患者，该患者既无酗酒史也无胃手术史。一名 56 岁女性因意识丧失转入我院，被诊断为 Wernicke 脑病。她表现为质子泵抑制剂诱导的难治性高胃泌素血症，随后出现顽固性呕吐和维生素 B1 缺乏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e09b/7691029/349d944efaed/1349-7235-59-2783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e09b/7691029/57cba399dd41/1349-7235-59-2783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e09b/7691029/349d944efaed/1349-7235-59-2783-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e09b/7691029/57cba399dd41/1349-7235-59-2783-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e09b/7691029/349d944efaed/1349-7235-59-2783-g002.jpg

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本文引用的文献

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A case of Wernicke's encephalopathy following complicated laparoscopic pylorus-preserving pancreaticoduodenectomy.一例复杂腹腔镜保留幽门胰十二指肠切除术后发生韦尼克脑病的病例。
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Does the Novel Potassium-Competitive Acid Blocker Vonoprazan Cause More Hypergastrinemia than Conventional Proton Pump Inhibitors? A Multicenter Prospective Cross-Sectional Study.新型钾离子竞争性酸阻滞剂沃诺拉赞是否比传统质子泵抑制剂引起更多的高胃泌素血症？一项多中心前瞻性横断面研究。
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Wernicke-Korsakoff syndrome not related to alcohol use: a systematic review.
非酒精相关性 Wernicke-Korsakoff 综合征：系统评价。
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The natural history and pathophysiology of Wernicke's Encephalopathy and Korsakoff's Psychosis.韦尼克脑病和科萨科夫精神病的自然病史及病理生理学
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Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas.慢性高胃泌素血症对人肠嗜铬样细胞的影响：来自散发性胃泌素瘤患者的见解。
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