Department of Radiology, Nagoya University Graduate School of Medicine.
Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine.
Magn Reson Med Sci. 2021 Sep 1;20(3):245-252. doi: 10.2463/mrms.mp.2020-0062. Epub 2020 Jul 14.
The purpose of this retrospective study was to investigate the relationship between the number and size of cystic structures around the cortical veins near the superior sagittal sinus and the leakage of gadolinium-based contrast agent (GBCA) around the cortical veins.
Of 190 patients (91 male and 99 female), that were scanned at 4 h after an intravenous injection of GBCA as a diagnostic examination for endolymphatic hydrops, 6 patients with GBCA leakage were younger than the previously proposed threshold age of 37.3 years for leakage. Six age-matched patients without leakage were also included for reference. In addition, we included 8 cases without leakage that were older than the hypothesized threshold of 37.3 years, as well as 8 age-matched patients with GBCA leakage into the cerebrospinal fluid space. The number of cysts was counted and the sizes were measured in these 28 patients (age: 32-60 years old, 13 men and 15 women).
The mean number of cysts surrounding the cortical veins in the parasagittal region was 4.29 ± 1.77 vs. 1.79 ± 1.05 (P = 0.0001) in the subjects with and without GBCA leakage, respectively. The mean size of the largest cysts was at 8.89 ± 3.49 mm vs. 5.69 ± 2.29 (P = 0.009) in the subjects with and without GBCA leakage, respectively.
The number and size of the perivenous cystic structures near the superior sagittal sinus is greater in subjects with GBCA leakage into the subarachnoid space compared with those without leakage. Future research regarding the histological and functional details of these parasagittal cystic structures is needed.
本回顾性研究旨在探讨上矢状窦皮质静脉周围囊性结构的数量和大小与皮质静脉周围钆基对比剂（GBCA）漏出之间的关系。
在 190 例（男 91 例，女 99 例）患者中，有 6 例（年龄均小于 37.3 岁，该年龄被认为是 GBCA 漏出的阈值年龄）在 GBCA 静脉注射后 4 小时进行了诊断性内淋巴积水扫描，出现 GBCA 漏出，另外还纳入了 6 例年龄匹配且无漏出的患者作为对照。此外，我们还纳入了 8 例无漏出但年龄大于 37.3 岁假设阈值的病例，以及 8 例年龄匹配且 GBCA 漏入脑脊液间隙的病例。在这 28 例患者（年龄 32-60 岁，男 13 例，女 15 例）中，对皮质静脉周围的囊数进行计数并测量其大小。
GBCA 漏出组和无漏出组患者在矢状旁区皮质静脉周围的平均囊数分别为 4.29 ± 1.77 个和 1.79 ± 1.05 个（P = 0.0001）。最大囊的平均大小分别为 8.89 ± 3.49 mm 和 5.69 ± 2.29 mm（P = 0.009）。
与无 GBCA 漏出的患者相比，GBCA 漏入蛛网膜下腔的患者上矢状窦皮质静脉周围的静脉旁囊性结构数量和大小更大。需要进一步研究这些矢状旁囊性结构的组织学和功能细节。
