Department of Radiology, Nagoya University Graduate School of Medicine.
Siemens Healthcare KK.
Magn Reson Med Sci. 2020 May 1;19(2):141-146. doi: 10.2463/mrms.mp.2019-0048. Epub 2019 Jun 20.
It has been reported that leakage of intravenously administered gadolinium-based contrast agents (IV-GBCAs) into the cerebrospinal fluid (CSF) from the cortical veins even in healthy subjects can be detected using a highly sensitive pulse sequence such as heavily T-weighted 3D fluid-attenuated inversion recovery and 3D-real inversion recovery (IR). The purpose of this study was to evaluate the feasibility of MR fingerprinting to detect GBCA leakage from the cortical veins after IV-GBCA.
Fourteen patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (39-79 years old) were included. The real IR images as well as MR fingerprinting images were obtained at 4 h after IV-GBCA. T and T values were obtained using MR fingerprinting and analyzed in ROIs covering intense GBCA leakage, and non-leakage areas of the CSF as determined on real IR images. The scan time for real IR imaging was 10 min and that for MR fingerprinting was 41 s.
The mean T value of the ROI in the area of GBCA leakage was 2422 ± 261 ms and that in the non-leakage area was 3851 ± 235 ms (P < 0.01). There was no overlap between the T values in the area of GBCA leakage and those in the non-leakage area.The mean T value in the area of GBCA leakage was 319 ± 90 ms and that in the non-leakage area was 670 ± 166 ms (P < 0.01). There was some overlap between the T values in the area of GBCA leakage and those in the non-leakage area.
Leaked GBCA from the cortical veins into the surrounding CSF can be detected using MR fingerprinting obtained in <1 min.
据报道，即使在健康受试者中，使用高度敏感的脉冲序列（如重度 T 加权 3D 液体衰减反转恢复和 3D 反转恢复[IR]）也可以检测到从皮质静脉漏入脑脊液（CSF）的静脉内给予的钆基造影剂（IV-GBCA）。本研究旨在评估磁共振指纹成像检测 IV-GBCA 后皮质静脉 GBCA 漏出的可行性。
纳入 14 例疑似内淋巴积水（EH）患者（39-79 岁），单次静脉注射 GBCA。IV-GBCA 后 4 小时获得真实 IR 图像和磁共振指纹成像图像。使用磁共振指纹成像获得 T 和 T 值，并在真实 IR 图像上确定的强烈 GBCA 泄漏和无泄漏 CSF 区域的 ROI 中进行分析。真实 IR 成像的扫描时间为 10 分钟，磁共振指纹成像的扫描时间为 41 秒。
GBCA 泄漏区域 ROI 的平均 T 值为 2422±261ms，无泄漏区域 ROI 的平均 T 值为 3851±235ms（P<0.01）。GBCA 泄漏区域和无泄漏区域的 T 值之间没有重叠。GBCA 泄漏区域 ROI 的平均 T 值为 319±90ms，无泄漏区域 ROI 的平均 T 值为 670±166ms（P<0.01）。GBCA 泄漏区域和无泄漏区域的 T 值之间存在一些重叠。
使用不到 1 分钟获得的磁共振指纹成像可以检测到从皮质静脉漏入周围 CSF 的 GBCA。
