Burguera-Giménez Noemi, García-Lázaro Santiago, España-Gregori Enrique, Gallego-Pinazo Roberto, Burguera-Giménez Neus, Rodríguez-Vallejo Manuel, Jonna Gowtham
Ophthalmology Department, Retina Research Center, Austin, Texas, USA.
Optometry Department, University of Valencia, Valencia, Spain.
Clin Ophthalmol. 2020 Jun 4;14:1533-1545. doi: 10.2147/OPTH.S246245. eCollection 2020.
To comprehensively evaluate visual function in eyes with geographic atrophy (GA) as compared to normal eyes.
Sixty-three eyes from 63 patients ≥50 years old were recruited for this observational study; 31 were identified as normal macular health eyes and 32 with GA. Visual function was tested with best corrected visual acuity (BCVA), low luminance visual acuity (LLVA), low luminance deficit (LLD), reading speed, macular integrity microperimetry, fixation stability, and contrast sensitivity function (CSF). Anatomic function was evaluated with spectral-domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF). Quality of life and vision were assessed with the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25).
Visual function and quality of life are reduced in patients with GA. Moderate and strong correlations in the GA group were found between maximum reading speed (r = 0.787) (p˂0.01), CS spatial frequency 3 cpd (r = 0.441) (p˂0.05), CS spatial frequency 6 cpd (r = 0.524) (p˂0.01), fixation P1 (r = 0.379) (p˂0.05), macular sensitivity (r = 0.484) (p˂0.05) and atrophic area (r = -0.689) (p˂0.01), and the VFQ-25 composite score.
The decreased visual function is reflected in a poor quality of life in patients with GA. Reading speed, contrast sensitivity, fixation, and macular sensitivity are strongly associated with vision-related quality of life. The results suggest the importance of the reading letter size in patients with GA. Microperimetry and reading speed are useful tools to better assess visual impairment in patients with GA.
与正常眼睛相比，全面评估地图样萎缩（GA）眼睛的视觉功能。
本观察性研究纳入了63例年龄≥50岁患者的63只眼睛；31只被确定为黄斑健康正常眼睛，32只患有GA。通过最佳矫正视力（BCVA）、低亮度视力（LLVA）、低亮度缺陷（LLD）、阅读速度、黄斑完整性微视野检查、注视稳定性和对比敏感度功能（CSF）测试视觉功能。通过频域光学相干断层扫描（SD-OCT）和眼底自发荧光（FAF）评估解剖功能。使用美国国立眼科研究所视觉功能问卷-25（NEI VFQ-25）评估生活质量和视力。
GA患者的视觉功能和生活质量降低。在GA组中，最大阅读速度（r = 0.787）（p<0.01）、CS空间频率3 cpd（r = 0.441）（p<0.05）、CS空间频率6 cpd（r = 0.524）（p<0.01）、注视P1（r = 0.379）（p<0.05）、黄斑敏感度（r = 0.484）（p<0.05）与萎缩面积（r = -0.689）（p<0.01）和VFQ-25综合评分之间存在中度和强相关性。
GA患者视觉功能下降反映在生活质量较差。阅读速度、对比敏感度、注视和黄斑敏感度与视力相关生活质量密切相关。结果表明GA患者阅读字母大小的重要性。微视野检查和阅读速度是更好评估GA患者视力损害的有用工具。
