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探索健康、身体特征和反社会行为结果的基因组结构:简要报告

Exploring the Genomic Architectures of Health, Physical Traits and Antisocial Behavioral Outcomes: A Brief Report.

作者信息

Tielbeek Jorim J, Boutwell Brian B

机构信息

Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

Department of Criminal Justice and Legal Studies, School of Applied Sciences, University of Mississippi, University, MS, United States.

出版信息

Front Psychiatry. 2020 Jun 25;11:539. doi: 10.3389/fpsyt.2020.00539. eCollection 2020.

Abstract

A widely replicated finding across the behavioral sciences is that antisocial behaviors correlate with an array of health problems. Less clear, however, is the precise nature of this association. There is reason to suspect that a direct causal link exists between incarceration-a consequence of some antisocial behaviors-and certain negative health outcomes, for instance. However, it might be the case that broader phenotypes like antisocial behavior may correlate with certain health and physiological traits at a genomic level. We explore this possibility from a theoretical vantage point, while also presenting some preliminary data from existing secondary sources. Tentatively, no significant genetic correlations emerged across a host of health, physiological, and wellbeing outcomes after correction for multiple testing. However, more work is needed exploring this topic. We propose that future studies should make use of larger, more diverse samples and examine the genetic overlap between homogeneous clusters of antisocial behavioral subtypes and disease traits or symptoms.

摘要

行为科学领域一个得到广泛重复验证的发现是,反社会行为与一系列健康问题相关。然而,这种关联的确切性质尚不清楚。例如,有理由怀疑监禁(某些反社会行为的一个后果)与某些负面健康结果之间存在直接因果联系。然而,情况可能是,像反社会行为这样更广泛的表型可能在基因组水平上与某些健康和生理特征相关。我们从理论角度探讨这种可能性,同时也展示一些来自现有二手资料的初步数据。初步来看,在进行多重检验校正后,在众多健康、生理和幸福结果中未出现显著的遗传相关性。然而,需要开展更多工作来探索这个主题。我们建议未来的研究应使用更大、更多样化的样本,并研究反社会行为亚型的同质集群与疾病特征或症状之间的遗传重叠。

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