Division of Life Sciences and Medicine, Department of Laboratory Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Division of Life Sciences and Medicine, Department of Medical Oncology, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Front Immunol. 2020 Jun 26;11:1315. doi: 10.3389/fimmu.2020.01315. eCollection 2020.
The barrier surfaces of the gastrointestinal tract are in constant contact with various microorganisms. Cytokines orchestrate the mucosal adaptive and innate immune cells in the defense against pathogens. IL-10 and IL-22 are the best studied members of the IL-10 family and play essential roles in maintaining mucosal homeostasis. IL-10 serves as an important regulator in preventing pro-inflammatory responses while IL-22 plays a protective role in tissue damage and contributes to pathology in certain settings. In this review, we focus on these two cytokines in the development of gastrointestinal diseases, including inflammatory bowel diseases (IBD) and colitis-associated cancer (CAC). We summarize the recent studies and try to gain a better understanding on how they regulate immune responses to maintain equilibrium under inflammatory conditions.
胃肠道的屏障表面与各种微生物不断接触。细胞因子协调黏膜适应性和先天免疫细胞抵抗病原体。IL-10 和 IL-22 是 IL-10 家族中研究最多的成员，在维持黏膜稳态方面发挥着重要作用。IL-10 作为一种重要的调节剂，可防止促炎反应，而 IL-22 在组织损伤中起保护作用，并在某些情况下导致病理学改变。在这篇综述中，我们重点关注这两种细胞因子在胃肠道疾病（包括炎症性肠病和结肠炎相关癌症）中的作用。我们总结了最近的研究成果，试图更好地了解它们如何调节免疫反应，以在炎症条件下维持平衡。
