Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Shanghai 200233, China.
Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai 201300, China.
Dis Markers. 2020 Jun 30;2020:8885286. doi: 10.1155/2020/8885286. eCollection 2020.
The sarcomeric proteins control the movement of cells in diverse species, whereas the deregulation can induce tumours in model organisms and occurs in human carcinomas. Sarcomeric proteins are recognized as oncogene and related to tumor cell metastasis. Recent insights into their expressions and functions have led to new cancer therapeutic opportunities. In this review, we appraise the evidence for the sarcomeric proteins as cancer genes and discuss cancer-relevant biological functions, potential mechanisms by which sarcomeric proteins activity is altered in cancer.
肌节蛋白控制着不同物种细胞的运动，而其失调会在模式生物中诱导肿瘤，并发生在人类癌中。肌节蛋白被认为是癌基因，与肿瘤细胞转移有关。最近对其表达和功能的深入了解为癌症的治疗提供了新的机会。在这篇综述中，我们评估了肌节蛋白作为癌症基因的证据，并讨论了与癌症相关的生物学功能，以及肌节蛋白活性在癌症中改变的潜在机制。
